Tbio ERCC3 General transcription and DNA repair factor IIH helicase subunit XPB

Protein Summary

Description

ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• P19447
• Q53QM0
• TFIIH subunit XPB

Gene Name

• ERCC3

Ensembl ID

• ENST00000285398
• ENSP00000285398
• ENSG00000163161

Symbol

• XPB
• XPBC
• XPB
• BTF2
• TTD2
• GTF2H
• RAD25
• TFIIH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.97
histone modification site profile	0.9
disease perturbation	0.83
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / General Transcription And Dna Repair Factor Iih Helicase Subunit Xpb

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / General Transcription And Dna Repair Factor Iih Helicase Subunit Xpb

Protein / Hydrolase / General Transcription And Dna Repair Factor Iih Helicase Subunit Xpb

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Tfiih Basal Transcription Factor Complex Helicase Xpb Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.32   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.32   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0