Tbio GGT1 Glutathione hydrolase 1 proenzyme

Protein Summary

Description

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P19440
• Q08247
• Q14404
• Q8TBS1
• Q9UMK1

Gene Name

• GGT1

Ensembl ID

• ENST00000248923
• ENSP00000248923
• ENSG00000100031
• ENST00000400380
• ENSP00000383231
• ENST00000400382
• ENSP00000383232
• ENST00000401885
• ENSP00000384381
• ENST00000403838
• ENSP00000384820
• ENST00000404532
• ENSP00000385445
• ENST00000425895
• ENSP00000387499

Symbol

• GGT
• GGT
• GTG
• GGTD
• CD224
• GGT 1
• D22S672
• D22S732

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
chemical	0.85
PubMedID	0.84
transcription factor perturbation	0.8
disease	0.78

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Glutathione Hydrolase 1 Proenzyme

Protein / Hydrolase / Protease / Glutathione Hydrolase 1 Proenzyme

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Glutathione Hydrolase 1 Proenzyme

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.69   (req: < 5)

Gene RIFs: 186   (req: <= 3)

Antibodies: 424   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.69   (req: >= 5)

Gene RIFs: 186   (req: > 3)

Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0