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Tchem
TNFRSF1A
Tumor necrosis factor receptor superfamily member 1A

Protein Summary
Description
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000162749
  • ENSP00000162749
  • ENSG00000067182
  • ENST00000366159
  • ENSP00000380389

Symbol
  • TNFAR
  • TNFR1
  • FPF
  • p55
  • p60
  • TBP1
  • TNF-R
  • TNFAR
  • TNFR1
  • p55-R
  • CD120a
  • TNFR55
  • TNFR60
  • TNF-R-I
  • TNF-R55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
transcription factor perturbation
0.94
virus perturbation
0.94
disease
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2778   (req: < 5)
Gene RIFs: 434   (req: <= 3)
Antibodies: 1327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2778   (req: >= 5)
Gene RIFs: 434   (req: > 3)
Antibodies: 1327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0