Tchem TNFRSF1A Tumor necrosis factor receptor superfamily member 1A

Protein Summary

Description

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• P19438
• A8K4X3
• B2RDE4
• B3KPQ1
• B4DQB7
• B4E309
• B5M0B5
• D3DUR1
• Q9UCA4

Gene Name

• TNFRSF1A

Ensembl ID

• ENST00000162749
• ENSP00000162749
• ENSG00000067182
• ENST00000366159
• ENSP00000380389

Symbol

• TNFAR
• TNFR1
• FPF
• p55
• p60
• TBP1
• TNF-R
• TNFAR
• TNFR1
• p55-R
• CD120a
• TNFR55
• TNFR60
• TNF-R-I
• TNF-R55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
transcription factor perturbation	0.94
virus perturbation	0.94
disease	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2778   (req: < 5)

Gene RIFs: 518   (req: <= 3)

Antibodies: 1327   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2778   (req: >= 5)

Gene RIFs: 518   (req: > 3)

Antibodies: 1327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0