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Tchem
TNFRSF1A
Tumor necrosis factor receptor superfamily member 1A

Protein Summary
Description
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000162749
  • ENSP00000162749
  • ENSG00000067182
  • ENST00000366159
  • ENSP00000380389

Symbol
  • TNFAR
  • TNFR1
  • FPF
  • p55
  • p60
  • TBP1
  • TNF-R
  • TNFAR
  • TNFR1
  • p55-R
  • CD120a
  • TNFR55
  • TNFR60
  • TNF-R-I
  • TNF-R55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
transcription factor perturbation
0.94
virus perturbation
0.94
disease
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2437.8   (req: < 5)
Gene RIFs: 434   (req: <= 3)
Antibodies: 1327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2437.8   (req: >= 5)
Gene RIFs: 434   (req: > 3)
Antibodies: 1327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (27)
CHEMBL359346
Rendered image for CHEMBL359346
CHEMBL357092
Rendered image for CHEMBL357092
CHEMBL150292
Rendered image for CHEMBL150292
CHEMBL356012
Rendered image for CHEMBL356012
CHEMBL356830
Rendered image for CHEMBL356830
CHEMBL151203
Rendered image for CHEMBL151203
CHEMBL150886
Rendered image for CHEMBL150886
CHEMBL423208
Rendered image for CHEMBL423208
CHEMBL146955
Rendered image for CHEMBL146955
Protein-Protein Interactions (390)
TRADD
Tbio
Novelty:  0.00560091
p_int:  0.999999992
p_ni:  4e-9
p_wrong:  4e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
SCAI
Tbio
Novelty:  0.0021735
p_int:  0.999999899
p_ni:  1.01e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.999998959
p_ni:  0.000001041
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999998581
p_ni:  0.000001419
Score:  0.912
Data Source:  BioPlex,STRINGDB
TNF
Tclin
Novelty:  0.00001457
p_int:  0.999996794
p_ni:  0.000002275
p_wrong:  9.3e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.999996643
p_ni:  0.000003357
Data Source:  BioPlex
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
p_int:  0.999976445
p_ni:  0.000023555
Data Source:  BioPlex
TPCN1
Tchem
Family:  IC
Novelty:  0.003844
p_int:  0.999939942
p_ni:  0.000060058
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999906484
p_ni:  0.000093516
Score:  0.199
Data Source:  BioPlex,STRINGDB
GPRC5B
Tbio
Family:  GPCR
Novelty:  0.05128765
p_int:  0.999820247
p_ni:  0.000179018
p_wrong:  7.36e-7
Data Source:  BioPlex
Pathways (136)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Regulation of TNFR1 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Death Receptor Signalling
Immune System
Interleukin-10 signaling
Regulation of TNFR1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
6
98
5
4
0
1.1
95.8
monocyte count
2
3
3
95.8
platelet crit
2
6
6
95.6
neutrophil percentage of leukocytes
2
3
3
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
6
98
0
1.1
95.8
monocyte count
3
95.8
platelet crit
6
95.6
neutrophil percentage of leukocytes
3
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 1A
VGNC:52079
466934
Macaque
TNF receptor superfamily member 1A
722033
Mouse
MGI:1314884
21937
Rat
RGD:621237
25625
Dog
TNF receptor superfamily member 1A
VGNC:47662
403634
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 1A
Macaque
TNF receptor superfamily member 1A
Mouse
Rat
Dog
TNF receptor superfamily member 1A
Publication Statistics
PubMed Score 2437.80
PubMed score by year
PubTator Score 1375.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title