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Tbio
TNNI3
Troponin I, cardiac muscle

Protein Summary
Description
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344887
  • ENSP00000341838
  • ENSG00000129991

Symbol
  • TNNC1
  • CMH7
  • RCM1
  • cTnI
  • CMD2A
  • TNNC1
  • CMD1FF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
kinase
0.99
biological term
0.94
molecular function
0.73
hub protein
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5149.31   (req: < 5)
Gene RIFs: 251   (req: <= 3)
Antibodies: 2305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5149.31   (req: >= 5)
Gene RIFs: 251   (req: > 3)
Antibodies: 2305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
troponin I3, cardiac type
VGNC:14759
735514
Macaque
troponin I3, cardiac type
698470
Mouse
MGI:98783
21954
Rat
RGD:62052
29248
Dog
troponin I3, cardiac type
VGNC:47689
403566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
troponin I3, cardiac type
Macaque
troponin I3, cardiac type
Mouse
Rat
Dog
troponin I3, cardiac type
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion homeostasis
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (27)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (182)
1 – 10 of 182
IFNA4
Tbio
Novelty: 0.04421984
p_int: 0.999969748
p_ni: 0.000030252
Score: 0.622
Data Source: BioPlex,STRINGDB
TNNC1
Tclin
Novelty: 0.03535727
Score: 0.999
Data Source: Reactome,STRINGDB
TNNT2
Tbio
Novelty: 0.00044568
Score: 0.998
Data Source: Reactome,STRINGDB
TNNT1
Tbio
Novelty: 0.00072003
Score: 0.993
Data Source: Reactome,STRINGDB
TNNT3
Tbio
Novelty: 0.0212335
Score: 0.989
Data Source: Reactome,STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
Score: 0.988
Data Source: Reactome,STRINGDB
MYH6
Tbio
Novelty: 0.00058671
Score: 0.987
Data Source: STRINGDB
TPM1
Tbio
Novelty: 0.00261206
Score: 0.986
Data Source: STRINGDB
MYBPC3
Tbio
Novelty: 0.00297478
Score: 0.986
Data Source: STRINGDB
MYL3
Tbio
Novelty: 0.00493817
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  5149.31

PubMed score by year
PubTator Score  1869.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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