Tbio ELK1 ETS domain-containing protein Elk-1

Protein Summary

Description

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P19419
• B2R7H4
• O75606
• O95058
• Q969X8
• Q9UJM4

Gene Name

• ELK1

Ensembl ID

• ENST00000247161
• ENSP00000247161
• ENSG00000126767
• ENST00000343894
• ENSP00000345585
• ENST00000376983
• ENSP00000366182

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.95
pathway	0.94
biological process	0.93
biological term	0.9
molecular function	0.9

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ets Domain-containing Protein Elk-1

Protein / Signaling Molecule / Ets Domain-containing Protein Elk-1

Protein / Nucleic Acid Binding / Ets Domain-containing Protein Elk-1

Protein / ... / Winged Helix/forkhead Transcription Factor / Ets Domain-containing Protein Elk-1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Ets Domain-containing Protein Elk-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: < 5)

Gene RIFs: 128   (req: <= 3)

Antibodies: 1171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: >= 5)

Gene RIFs: 128   (req: > 3)

Antibodies: 1171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0