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Tbio
ELK1
ETS domain-containing protein Elk-1

Protein Summary
Description
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247161
  • ENSP00000247161
  • ENSG00000126767
  • ENST00000343894
  • ENSP00000345585
  • ENST00000376983
  • ENSP00000366182
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
pathway
0.94
biological process
0.93
biological term
0.9
molecular function
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 1171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 1171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.976
Data Source:  Reactome,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.968
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.962
Data Source:  Reactome,STRINGDB
MYOCD
Tbio
Novelty:  0.00354211
Score:  0.956
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.95
Data Source:  Reactome,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.943
Data Source:  STRINGDB
PRRT2
Tbio
Novelty:  0.00442931
Score:  0.943
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.923
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.915
Data Source:  STRINGDB
RPS6KA3
Tchem
Family:  Kinase
Novelty:  0.00221219
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  14
more:  10 more common pathways
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  15
more:  11 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  11
more:  7 more common pathways
RAF1
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  13
more:  9 more common pathways
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  6
more:  2 more common pathways
Pathways (124)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
ERK/MAPK targets
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome
Extra-nuclear estrogen signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
ERK/MAPK targets
ESR-mediated signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Extra-nuclear estrogen signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELK1, ETS transcription factor
VGNC:12308
473591
Mouse
MGI:101833
13712
Rat
RGD:1598663
314436
Dog
ELK1, ETS transcription factor
VGNC:40303
491860
Horse
ELK1, ETS transcription factor
VGNC:17523
100051388
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELK1, ETS transcription factor
Mouse
Rat
Dog
ELK1, ETS transcription factor
Horse
ELK1, ETS transcription factor
Publication Statistics
PubMed Score 8.58
PubMed score by year
PubTator Score 110.64
PubTator score by year
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Related Publications
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PMID
Year
Title