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Tclin
NDUFV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318388
  • ENSP00000327268
  • ENSG00000178127

Symbol
  • CI-24k
  • MC1DN7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.86
transcription factor perturbation
0.8
cellular component
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.35   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.35   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.99999412
p_ni:  0.00000588
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.999931117
p_ni:  0.000068883
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.999465786
p_ni:  0.000534214
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.999077408
p_ni:  0.000922592
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA7
Tclin
Family:  Enzyme
Novelty:  0.16417588
p_int:  0.998019565
p_ni:  0.001980435
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFB3
Tclin
Family:  Enzyme
Novelty:  0.13020753
p_int:  0.994220644
p_ni:  0.005779356
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA8
Tclin
Family:  Enzyme
Novelty:  0.05772867
p_int:  0.99382702
p_ni:  0.00617298
Score:  0.999
Data Source:  BioPlex,STRINGDB
RASSF1
Tbio
Novelty:  0.00137149
p_int:  0.949837924
p_ni:  0.050162076
Score:  0.234
Data Source:  BioPlex,STRINGDB
NDUFA12
Tclin
Family:  Enzyme
Novelty:  0.04679316
p_int:  0.945849825
p_ni:  0.054150175
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.759983875
p_ni:  0.240016125
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
56.6
heel bone mineral density
1
1
1
42.3
self reported educational attainment
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
56.6
heel bone mineral density
1
42.3
self reported educational attainment
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit V2
455295
Mouse
MGI:1920150
72900
Rat
RGD:621733
81728
Dog
NADH:ubiquinone oxidoreductase core subunit V2
VGNC:53624
480204
Horse
NADH:ubiquinone oxidoreductase core subunit V2
VGNC:50955
100054445
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit V2
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit V2
Horse
NADH:ubiquinone oxidoreductase core subunit V2
Publication Statistics
PubMed Score 46.35
PubMed score by year
PubTator Score 28.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title