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Tbio
CD53
Leukocyte surface antigen CD53

Protein Summary
Description
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271324
  • ENSP00000271324
  • ENSG00000143119
  • ENST00000648608
  • ENSP00000497382

Symbol
  • MOX44
  • TSPAN25
  • MOX44
  • TSPAN25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
gene perturbation
0.91
kinase perturbation
0.88
transcription factor perturbation
0.84
tissue sample
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.19   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 603   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.19   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 603   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD53 molecule
VGNC:10559
745007
Macaque
CD53 molecule
702350
Mouse
MGI:88341
12508
Rat
RGD:2310
24251
Dog
CD53 molecule
VGNC:38964
100855953
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD53 molecule
Macaque
CD53 molecule
Mouse
Rat
Dog
CD53 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19397-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (215)
1 – 10 of 215
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.976
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.955
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.952
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.951
Data Source: STRINGDB
LILRB2
Tbio
Novelty: 0.00545569
Score: 0.95
Data Source: STRINGDB
CD300A
Tbio
Novelty: 0.01745189
Score: 0.95
Data Source: STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.947
Data Source: STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
Score: 0.939
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.938
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00286826
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.19

PubMed score by year
PubTator Score  471.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer