Tbio POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P19388
• B2R6L4
• D6W5Y1
• O43380
• Q6PIH5
• Q9BT06
• RNA polymerases I, II, and III subunit ABC1

Gene Name

• POLR2E

Ensembl ID

• ENST00000586746
• ENSP00000464739
• ENSG00000099817
• ENST00000612655
• ENSP00000485021
• ENST00000615234
• ENSP00000478303

Symbol

• RPB5
• XAP4
• RPABC1
• hRPB25
• hsRPB5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.93
hub protein	0.92
biological process	0.87
protein complex	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc1

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc1

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I, Ii, And Iii Subunit Rpabc1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.64   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 278   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.64   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0