You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POLR2C
DNA-directed RNA polymerase II subunit RPB3

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219252
  • ENSP00000219252
  • ENSG00000102978

Symbol
  • RPB3
  • RPB31
  • hRPB33
  • hsRPB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
disease perturbation
0.96
kinase perturbation
0.81
biological process
0.78
pathway
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.23   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.23   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (691)
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999191282
p_ni:  0.000808718
Score:  0.999
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.997607469
p_ni:  0.002392531
Score:  0.618
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.986906431
p_ni:  0.013093569
Score:  0.872
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.941753891
p_ni:  0.058246109
Score:  0.842
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.939261787
p_ni:  0.06073821
p_wrong:  3e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.930481907
p_ni:  0.069518093
Score:  0.635
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.920784649
p_ni:  0.079215351
Score:  0.763
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.900010761
p_ni:  0.099989239
Score:  0.999
Data Source:  BioPlex,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.999
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (76)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Repair
Developmental Biology
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
1
1
86.9
CCL17 measurement
1
1
1
79.4
blood protein measurement
1
1
1
76.7
eosinophil count
1
1
1
52.7
mosaic loss of chromosome Y measurement
2
1
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
86.9
CCL17 measurement
1
79.4
blood protein measurement
1
76.7
eosinophil count
1
52.7
mosaic loss of chromosome Y measurement
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit C
VGNC:8993
454119
Macaque
RNA polymerase II subunit C
704555
Mouse
MGI:109299
20021
Rat
RGD:1306935
361365
Dog
RNA polymerase II subunit C
VGNC:44794
478109
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit C
Macaque
RNA polymerase II subunit C
Mouse
Rat
Dog
RNA polymerase II subunit C
Publication Statistics
PubMed Score 56.23
PubMed score by year
PubTator Score 12.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title