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Tchem
HK1
Hexokinase-1

Protein Summary
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298649
  • ENSP00000298649
  • ENSG00000156515
  • ENST00000359426
  • ENSP00000352398
  • ENST00000360289
  • ENSP00000353433
  • ENST00000436817
  • ENSP00000415949
  • ENST00000448642
  • ENSP00000402103
  • ENST00000643399
  • ENSP00000494664

Symbol
  • HK
  • HKD
  • HKI
  • HXK1
  • RP79
  • HMSNR
  • HK1-ta
  • HK1-tb
  • HK1-tc
  • hexokinase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
molecular function
0.95
gene perturbation
0.85
PubMedID
0.83
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.49   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 776   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.49   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 776   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
5
5
8
99.1
hemoglobin measurement
4
3
4
96.3
hematocrit
4
3
4
95.8
mean corpuscular hemoglobin concentration
1
1
1
85
red blood cell density measurement
1
1
1
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
8
99.1
hemoglobin measurement
4
96.3
hematocrit
4
95.8
mean corpuscular hemoglobin concentration
1
85
red blood cell density measurement
1
85
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (35)
Defective HK1 causes hexokinase deficiency (HK deficiency) (R-HSA-5619056)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective HK1 causes hexokinase deficiency (HK deficiency)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Glucose metabolism
Reactome
Glycolysis
Name
Explore in Pharos
Explore in Source
Defective HK1 causes hexokinase deficiency (HK deficiency)
Disease
Disorders of transmembrane transporters
Glucose metabolism
Glycolysis
Gene Ontology Terms (20)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (268)
1 – 10 of 268
HKDC1
Tbio
Family: Kinase
Novelty: 0.016969
p_int: 1
Score: 0.986
Data Source: BioPlex,STRINGDB
HK2
Tchem
Family: Kinase
Novelty: 0.00144136
p_int: 0.999759841
p_ni: 0.000240159
Score: 0.986
Data Source: BioPlex,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.99583932
p_ni: 0.002136622
p_wrong: 0.002024058
Score: 0.277
Data Source: BioPlex,STRINGDB
SNCA
Tchem
Novelty: 0.00012042
p_int: 0.992731345
p_ni: 0.007268655
Score: 0.254
Data Source: BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
p_int: 0.989204079
p_ni: 0.010795818
p_wrong: 1.02e-7
Score: 0.332
Data Source: BioPlex,STRINGDB
HK3
Tbio
Family: Kinase
Novelty: 0.0151241
p_int: 0.979281567
p_ni: 0.020718433
Score: 0.974
Data Source: BioPlex,STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.989
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00064455
Score: 0.989
Data Source: STRINGDB
KHK
Tchem
Family: Kinase
Novelty: 0.00514172
Score: 0.971
Data Source: STRINGDB
MPI
Tchem
Family: Enzyme
Novelty: 0.0091718
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  500.49

PubMed score by year
PubTator Score  1998.01

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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