Protein Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]
- ENST00000298649
- ENSP00000298649
- ENSG00000156515
- ENST00000359426
- ENSP00000352398
- ENST00000360289
- ENSP00000353433
- ENST00000436817
- ENSP00000415949
- ENST00000448642
- ENSP00000402103
- ENST00000643399
- ENSP00000494664
- HK
- HKD
- HKI
- HXK1
- RP79
- HMSNR
- HK1-ta
- HK1-tb
- HK1-tc
- hexokinase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
molecular function | 0.95 | ||
gene perturbation | 0.85 | ||
PubMedID | 0.83 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 468.94 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 776 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 468.94 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 776 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0