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Tbio
NCL
Nucleolin

Protein Summary
Description
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322723
  • ENSP00000318195
  • ENSG00000115053

Symbol
  • C23
  • Nsr1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
hub protein
1
interacting protein
1
disease perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 981.58   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 804   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 981.58   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
74
body height
1
1
1
42.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
74
body height
1
42.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97286
17975
Rat
RGD:3153
25135
Dog
nucleolin
VGNC:43657
608445
Horse
nucleolin
VGNC:20593
100034004
Cow
nucleolin
497013
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
nucleolin
Horse
nucleolin
Cow
nucleolin
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (395)
1 – 10 of 395
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.986639714
p_ni: 0.013360286
Score: 0.562
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.983832456
p_ni: 0.016167544
Score: 0.493
Data Source: BioPlex,STRINGDB
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.934320955
p_ni: 0.065679045
Score: 0.585
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.923911529
p_ni: 0.076088471
Score: 0.61
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.857853674
p_ni: 0.142146326
Score: 0.962
Data Source: BioPlex,STRINGDB
EBNA1BP2
Tbio
Novelty: 0.02083466
p_int: 0.819417654
p_ni: 0.180582346
Score: 0.846
Data Source: BioPlex,STRINGDB
NPM1
Tbio
Novelty: 0.0005485
p_int: 0.771500097
p_ni: 0.228499903
Score: 0.998
Data Source: BioPlex,STRINGDB
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.750310872
p_ni: 0.249689128
Score: 0.244
Data Source: BioPlex,STRINGDB
FBL
Tbio
Family: Enzyme
Novelty: 0.00080634
Score: 0.993
Data Source: STRINGDB
WDR43
Tbio
Novelty: 0.12680949
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  981.58

PubMed score by year
PubTator Score  1190

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer