CD58
Lymphocyte function-associated antigen 3
Protein Summary
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
- ENST00000369489
- ENSP00000358501
- ENSG00000116815
- ENST00000457047
- ENSP00000409080
- ENST00000464088
- ENSP00000432773
- LFA3
- ag3
- LFA3
- LFA-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.8 | ||
small molecule perturbation | 0.74 | ||
tissue | 0.65 | ||
histone modification site profile | 0.63 | ||
transcription factor binding site profile | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 456 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 792 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 456 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 792 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0