CD58
Lymphocyte function-associated antigen 3
Protein Summary
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
- ENST00000369489
- ENSP00000358501
- ENSG00000116815
- ENST00000457047
- ENSP00000409080
- ENST00000464088
- ENSP00000432773
- LFA3
- ag3
- LFA3
- LFA-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.8 | ||
small molecule perturbation | 0.74 | ||
tissue | 0.65 | ||
histone modification site profile | 0.63 | ||
transcription factor binding site profile | 0.63 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 436.23 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 792 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 436.23 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 792 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
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1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 4 | 0 | 1.3 | 98.6 | |||||
1 | 1 | 0 | 1.3 | 64.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 98.6 | |||||
0 | 1.3 | 64.4 | |||||
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD58 molecule | VGNC:5014 | 457154 | |||||
Macaque | CD58 molecule | 710732 | ||||||
Horse | CD58 molecule | VGNC:50818 | 100066062 | |||||
Cow | CD58 molecule | VGNC:27040 | 782186 | |||||
Pig | CD58 molecule | 396702 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD58 molecule | |||||
Macaque | CD58 molecule | |||||
Horse | CD58 molecule | |||||
Cow | CD58 molecule | |||||
Pig | CD58 molecule | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (7)
Reactome (5)
KEGG (2)
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Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (15)
Functions (1)
Components (7)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (132)
1 – 10 of 132
LGALS3
Novelty: 0.00032754
p_int: 0.981905504
p_ni: 0.017454281
p_wrong: 0.000640215
Score: 0.265
Data Source: BioPlex,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.960772007
p_ni: 0.038667336
p_wrong: 0.000560657
Data Source: BioPlex
LGALS9
Novelty: 0.00381766
p_int: 0.945279658
p_ni: 0.054688041
p_wrong: 0.000032301
Score: 0.346
Data Source: BioPlex,STRINGDB
ABHD12B
Family: Enzyme
Novelty: 0.74329172
p_int: 0.81707308
p_ni: 0.048206069
p_wrong: 0.134720851
Score: 0.689
Data Source: BioPlex,STRINGDB
RFC4
Novelty: 0.03232586
p_int: 0.778112949
p_ni: 0.124353659
p_wrong: 0.097533392
Score: 0.189
Data Source: BioPlex,STRINGDB
CD2
Novelty: 0.00037283
Score: 0.999
Data Source: Reactome,STRINGDB
ICAM1
Novelty: 0.00009746
Score: 0.839
Data Source: STRINGDB
LGALS9C
Novelty: 0.29969898
Score: 0.756
Data Source: STRINGDB
CD80
Novelty: 0.00031181
Score: 0.745
Data Source: STRINGDB
ITGAL
Novelty: 0.00099016
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score 436.23
PubMed score by year
PubTator Score 337.74
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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