You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CD58
Lymphocyte function-associated antigen 3

Protein Summary
Description
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369489
  • ENSP00000358501
  • ENSG00000116815
  • ENST00000457047
  • ENSP00000409080
  • ENST00000464088
  • ENSP00000432773

Symbol
  • LFA3
  • ag3
  • LFA3
  • LFA-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.8
small molecule perturbation
0.74
tissue
0.65
histone modification site profile
0.63
transcription factor binding site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.23   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 792   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.23   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 792   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.3
98.6
1
1
0
1.3
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
98.6
0
1.3
64.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD58 molecule
VGNC:5014
457154
Macaque
CD58 molecule
710732
Horse
CD58 molecule
VGNC:50818
100066062
Cow
CD58 molecule
VGNC:27040
782186
Pig
CD58 molecule
396702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD58 molecule
Macaque
CD58 molecule
Horse
CD58 molecule
Cow
CD58 molecule
Pig
CD58 molecule
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19256-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (132)
1 – 10 of 132
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.981905504
p_ni: 0.017454281
p_wrong: 0.000640215
Score: 0.265
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.960772007
p_ni: 0.038667336
p_wrong: 0.000560657
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.945279658
p_ni: 0.054688041
p_wrong: 0.000032301
Score: 0.346
Data Source: BioPlex,STRINGDB
ABHD12B
Tdark
Family: Enzyme
Novelty: 0.74329172
p_int: 0.81707308
p_ni: 0.048206069
p_wrong: 0.134720851
Score: 0.689
Data Source: BioPlex,STRINGDB
RFC4
Tbio
Novelty: 0.03232586
p_int: 0.778112949
p_ni: 0.124353659
p_wrong: 0.097533392
Score: 0.189
Data Source: BioPlex,STRINGDB
CD2
Tclin
Novelty: 0.00037283
Score: 0.999
Data Source: Reactome,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.839
Data Source: STRINGDB
LGALS9C
Tdark
Novelty: 0.29969898
Score: 0.756
Data Source: STRINGDB
CD80
Tclin
Novelty: 0.00031181
Score: 0.745
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score  436.23

PubMed score by year
PubTator Score  337.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer