Protein Summary
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided ...more
- ENST00000222139
- ENSP00000222139
- ENSG00000187266
- ENST00000592375
- ENSP00000467809
- EPO-R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.92 | ||
hub protein | 0.9 | ||
kinase perturbation | 0.84 | ||
virus perturbation | 0.76 | ||
gene perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 837.54 (req: < 5)
Gene RIFs: 144 (req: <= 3)
Antibodies: 822 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 837.54 (req: >= 5)
Gene RIFs: 144 (req: > 3)
Antibodies: 822 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (7)
Active Ligands (10)
Protein-Protein Interactions (170)
EPO
Novelty: 0.00013701
p_int: 0.966331816
p_ni: 7.7e-8
p_wrong: 0.033668107
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (168)
Reactome (6)
KEGG (5)
PathwayCommons (7)
WikiPathways (150)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | ||||
Reactome | Erythropoietin activates Phospholipase C gamma (PLCG) | ||||
Reactome | Erythropoietin activates RAS | ||||
Reactome | Erythropoietin activates STAT5 | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | ||||
Erythropoietin activates Phospholipase C gamma (PLCG) | ||||
Erythropoietin activates RAS | ||||
Erythropoietin activates STAT5 | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 2 | 2 | 2 | 89.5 | |||||
total cholesterol measurement | 2 | 2 | 2 | 80.2 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 76.5 | |||||
3 | 1 | 1 | 7.8 | 65.4 | |||||
Calcium channel blocker use measurement | 1 | 1 | 1 | 64.9 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 2 | 89.5 | |||||
total cholesterol measurement | 2 | 80.2 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 76.5 | |||||
1 | 7.8 | 65.4 | |||||
Calcium channel blocker use measurement | 1 | 64.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | erythropoietin receptor | VGNC:2388 | 455728 | |||||
Mouse | MGI:95408 | 13857 | ||||||
Rat | RGD:2560 | 24336 | ||||||
Dog | erythropoietin receptor | VGNC:40424 | 484943 | |||||
Horse | erythropoietin receptor | VGNC:17634 | 100057022 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | erythropoietin receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | erythropoietin receptor | |||||
Horse | erythropoietin receptor | |||||
Publication Statistics
PubMed Score 837.54
PubMed score by year
PubTator Score 410.27
PubTator score by year
Related Publications
Text Mined References (223)
GeneRif Annotations (144)
Items per page:
0 of 0
PMID | Year | Title |
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