Tclin EPOR Erythropoietin receptor

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Erythropoietin Receptor

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Erythropoietin Receptor

Protein Summary

Description

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• P19235
• B2RCG4
• Q15443
• Q2M205
• EPO-R

Gene Name

• EPOR

Ensembl ID

• ENST00000222139
• ENSP00000222139
• ENSG00000187266
• ENST00000592375
• ENSP00000467809

Symbol

• EPO-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.92
hub protein	0.9
kinase perturbation	0.84
virus perturbation	0.76
gene perturbation	0.74

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 827.49   (req: < 5)

Gene RIFs: 144   (req: <= 3)

Antibodies: 822   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 827.49   (req: >= 5)

Gene RIFs: 144   (req: > 3)

Antibodies: 822   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7

Approved Drugs (7)

Explore Approved Drugs

1 – 7 of 7

epoetin alfa

EPORTclin

AGONIST IC50 : 11.15

peginesatide

EPORTclin

AGONIST IC50 : 10.43

epoetin theta

EPORTclin

AGONIST :

darbepoetin alfa

EPORTclin

AGONIST :

epoetin beta

EPORTclin

AGONIST :

methoxy polyethylene glycol-epoetin beta

EPORTclin

AGONIST :

epoetin zeta

EPORTclin

AGONIST :

GWAS Traits (1)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
erythropoetin measurement	EFO_0008391	1	1	0	1.5	73.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
erythropoetin measurement	EFO_0008391	0	1.5	73.8

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	erythropoietin receptor	VGNC:2388	455728
Mouse	erythropoietin receptor	MGI:95408	13857
Rat	erythropoietin receptor	RGD:2560	24336
Dog	erythropoietin receptor	VGNC:40424	484943
Horse	erythropoietin receptor	VGNC:17634	100057022

Species	Name	OMA	EggNOG	Inparanoid
Chimp	erythropoietin receptor
Mouse	erythropoietin receptor
Rat	erythropoietin receptor
Dog	erythropoietin receptor
Horse	erythropoietin receptor

Protein Structure (11 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19235-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (168)

Reactome (6)

KEGG (5)

PathwayCommons (7)

WikiPathways (150)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (R-HSA-9027276)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12 targets	R-HSA-9027276
Reactome	Erythropoietin activates Phospholipase C gamma (PLCG)	7 targets	R-HSA-9027277
Reactome	Erythropoietin activates RAS	14 targets	R-HSA-9027284
Reactome	Erythropoietin activates STAT5	7 targets	R-HSA-9027283
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12 targets	R-HSA-9027276
Erythropoietin activates Phospholipase C gamma (PLCG)	7 targets	R-HSA-9027277
Erythropoietin activates RAS	14 targets	R-HSA-9027284
Erythropoietin activates STAT5	7 targets	R-HSA-9027283
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (11)

Functions (2)

Components (3)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
erythropoietin receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Protein-Protein Interactions (170)

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1 – 10 of 170

• See Interactions on String-DB

EPO

Tbio

Novelty: 0.00013701

p_int: 0.966331816

p_ni: 7.7e-8

p_wrong: 0.033668107

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

JAK2

Tclin

Family: Kinase

Novelty: 0.00022894

Score: 0.995

Data Source: Reactome,STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00074026

Score: 0.989

Data Source: Reactome,STRINGDB

STAT5B

Tchem

Family: TF

Novelty: 0.00074178

Score: 0.982

Data Source: Reactome,STRINGDB

LYN

Tclin

Family: Kinase

Novelty: 0.00097393

Score: 0.976

Data Source: Reactome,STRINGDB

PLCG1

Tchem

Family: Enzyme

Novelty: 0.00110273

Score: 0.971

Data Source: Reactome,STRINGDB

KIT

Tclin

Family: Kinase

Novelty: 0.00011237

Score: 0.97

Data Source: STRINGDB

KITLG

Tbio

Novelty: 0.00036337

Score: 0.97

Data Source: STRINGDB

GRB2

Tchem

Novelty: 0.00091605

Score: 0.965

Data Source: Reactome,STRINGDB

SOCS3

Tbio

Novelty: 0.00106095

Score: 0.963

Data Source: STRINGDB

Publication Statistics

PubMed Score  827.49

PubMed score by year

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PubTator Score  410.27

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell membrane
Complete proteome
Congenital erythrocytosis
Disease mutation
Disulfide bond
Glycoprotein
Isopeptide bond
Membrane

GWAS Trait Find Similar Targets

erythropoetin measurement

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
embryo phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging
muscle phenotype
nervous system phenotype
respiratory system phenotype