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Tbio
UGT1A6
UDP-glucuronosyltransferase 1-6

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305139
  • ENSP00000303174
  • ENSG00000167165
  • ENST00000373424
  • ENSP00000362523

Symbol
  • GNT1
  • UGT1
  • GNT1
  • UGT1
  • HLUGP
  • UDPGT
  • UGT1A
  • UGT1C
  • UGT1E
  • UGT1F
  • HLUGP1
  • UGT-1A
  • UGT-1C
  • UGT-1E
  • UGT1.1
  • UGT1.3
  • UGT1.5
  • UGT1A1
  • UGT1A3
  • UGT1A5
  • UGT1-01
  • UGT1-03
  • UGT1-05
  • UGT1A6S
  • hUG-BR1
  • UDPGT 1-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
chemical
0.88
trait
0.86
molecular function
0.79
disease
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 784.93   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 784.93   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
16
74
136
100
vitamin D measurement
4
5
5
96.7
blood metabolite measurement
1
2
8
95.6
testosterone measurement
7
4
7
92.6
serum metabolite measurement
2
2
10
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
136
100
vitamin D measurement
5
96.7
blood metabolite measurement
8
95.6
testosterone measurement
7
92.6
serum metabolite measurement
10
92.6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19224-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (149)
1 – 10 of 149
UGT1A3
Tbio
Family:  Enzyme
Novelty:  0.01005508
Score:  0.995
Data Source:  STRINGDB
UGT1A4
Tbio
Family:  Enzyme
Novelty:  0.00731132
Score:  0.995
Data Source:  STRINGDB
UGT1A9
Tbio
Family:  Enzyme
Novelty:  0.0047848
Score:  0.994
Data Source:  STRINGDB
UGT1A7
Tbio
Family:  Enzyme
Novelty:  0.01095445
Score:  0.993
Data Source:  STRINGDB
UGT1A1
Tchem
Family:  Enzyme
Novelty:  0.00135044
Score:  0.993
Data Source:  STRINGDB
UGT1A8
Tbio
Family:  Enzyme
Novelty:  0.00135129
Score:  0.993
Data Source:  STRINGDB
UGT1A10
Tbio
Family:  Enzyme
Novelty:  0.01535804
Score:  0.993
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.957
Data Source:  STRINGDB
SLC35A2
Tbio
Family:  Transporter
Novelty:  0.00072521
Score:  0.939
Data Source:  STRINGDB
NFE2L2
Tchem
Family:  TF
Novelty:  0.00043828
Score:  0.937
Data Source:  STRINGDB
Publication Statistics
PubMed Score  784.93

PubMed score by year
PubTator Score  155.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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