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Tchem
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Protein Classes
Protein Summary
Description
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth fact ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244007
  • ENSP00000244007
  • ENSG00000124181
  • ENST00000373271
  • ENSP00000362368

Symbol
  • PLC1
  • PLC1
  • NCKAP3
  • PLC-II
  • PLC148
  • PLCgamma1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
biological process
0.99
kinase
0.99
pathway
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.72   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 1052   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.72   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 1052   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
92
low density lipoprotein cholesterol measurement
2
2
3
90.3
apolipoprotein B measurement
1
1
1
60
total cholesterol measurement
1
1
2
57.8
triglyceride measurement
1
1
1
29.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
92
low density lipoprotein cholesterol measurement
3
90.3
apolipoprotein B measurement
1
60
total cholesterol measurement
2
57.8
triglyceride measurement
1
29.6
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (204)
Activated NTRK2 signals through PLCG1 (R-HSA-9026527)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 75
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through PLCG1
Reactome
Activated NTRK3 signals through PLCG1
Reactome
Adaptive Immune System
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through PLCG1
Activated NTRK3 signals through PLCG1
Adaptive Immune System
Antiviral mechanism by IFN-stimulated genes
Axon guidance
Gene Ontology Terms (41)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (483)
1 – 10 of 483
DPYSL4
Tbio
Family: Enzyme
Novelty: 0.0449179
p_int: 0.999998927
p_ni: 0.000001073
Data Source: BioPlex
DOK2
Tbio
Novelty: 0.02651438
p_int: 0.999916588
p_ni: 0.000083412
Score: 0.35
Data Source: BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty: 0.07453111
p_int: 0.999913627
p_ni: 0.000086373
Data Source: BioPlex
GAS2L1
Tbio
Novelty: 0.17484834
p_int: 0.999881253
p_ni: 0.000118747
Data Source: BioPlex
MT1F
Tbio
Novelty: 0.03838808
p_int: 0.999877638
p_ni: 0.000122362
Data Source: BioPlex
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
p_int: 0.999281226
p_ni: 0.000718774
Data Source: BioPlex
KHDRBS2
Tbio
Novelty: 0.01986638
p_int: 0.99878948
p_ni: 0.001210284
p_wrong: 2.36e-7
Score: 0.274
Data Source: BioPlex,STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
p_int: 0.997612811
p_ni: 0.002387186
p_wrong: 3e-9
Data Source: BioPlex
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00153551
p_int: 0.995095929
p_ni: 0.004904068
p_wrong: 3e-9
Score: 0.202
Data Source: BioPlex,STRINGDB
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.991666434
p_ni: 0.008333103
p_wrong: 4.63e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  883.72

PubMed score by year
PubTator Score  428.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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