Tbio MYL12A Myosin regulatory light chain 12A

Protein Summary

Description

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• P19105
• Q53X45

Gene Name

• MYL12A

Ensembl ID

• ENST00000217652
• ENSP00000217652
• ENSG00000101608
• ENST00000536605
• ENSP00000441231
• ENST00000578611
• ENSP00000463614
• ENST00000579226
• ENSP00000462171

Symbol

• MLCB
• MRLC3
• RLC
• MLCB
• MRCL3
• MRLC3
• MYL2B
• MLC-2B
• HEL-S-24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Myosin Regulatory Light Chain 12a

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Myosin Regulatory Light Chain 12a

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Myosin Regulatory Light Chain 12a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.43   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.43   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0