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Tchem
CYP11B2
Cytochrome P450 11B2, mitochondrial

Protein Summary
Description
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323110
  • ENSP00000325822
  • ENSG00000179142

Symbol
  • CPN2
  • ALDOS
  • CYP11B
  • CYP11BL
  • CYPXIB2
  • P450C18
  • P-450C18
  • P450aldo
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.92
disease
0.86
cell type or tissue
0.84
phenotype
0.77
molecular function
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 835.76   (req: < 5)
Gene RIFs: 210   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 835.76   (req: >= 5)
Gene RIFs: 210   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1318
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (1318)
1 – 10 of 1318
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
94.5
1
3
3
66.2
diastolic blood pressure
2
4
4
65.4
androstenedione measurement
1
3
3
55.2
systolic blood pressure
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
94.5
3
66.2
diastolic blood pressure
4
65.4
androstenedione measurement
3
55.2
systolic blood pressure
1
53.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88583
110115
Rat
Dog
cytochrome P450, family 11, subfamily B, polypeptide 2
482071
Horse
cytochrome P450 11B1, mitochondrial-like
100063645
Cow
cytochrome P450 11B1, mitochondrial
787628
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cytochrome P450, family 11, subfamily B, polypeptide 2
Horse
cytochrome P450 11B1, mitochondrial-like
Cow
cytochrome P450 11B1, mitochondrial
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19099-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Disease
Diseases of metabolism
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
Score:  0.977
Data Source:  STRINGDB
HSD3B1
Tchem
Family:  Enzyme
Novelty:  0.0019271
Score:  0.972
Data Source:  STRINGDB
HSD17B6
Tbio
Family:  Enzyme
Novelty:  0.01428594
Score:  0.969
Data Source:  STRINGDB
HSD11B2
Tchem
Family:  Enzyme
Novelty:  0.00182237
Score:  0.969
Data Source:  STRINGDB
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
Score:  0.952
Data Source:  STRINGDB
CYP17A1
Tclin
Family:  Enzyme
Novelty:  0.00065091
Score:  0.949
Data Source:  STRINGDB
HSD11B1
Tclin
Family:  Enzyme
Novelty:  0.00105097
Score:  0.946
Data Source:  STRINGDB
CYP21A2
Tchem
Family:  Enzyme
Novelty:  0.00110959
Score:  0.946
Data Source:  STRINGDB
HSD17B2
Tchem
Family:  Enzyme
Novelty:  0.00960865
Score:  0.945
Data Source:  STRINGDB
CYP11B1
Tclin
Family:  Enzyme
Novelty:  0.00195229
Score:  0.945
Data Source:  STRINGDB
Publication Statistics
PubMed Score  835.76

PubMed score by year
PubTator Score  568.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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