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Tbio
GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615612
  • ENSP00000478892
  • ENSG00000128266

Symbol
  • gz-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.86
cellular component
0.81
cell type or tissue
0.79
histone modification site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
53.7
lymphocyte count
2
2
2
44.1
bone density
2
2
2
37.3
heel bone mineral density
1
1
1
29
handedness
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
53.7
lymphocyte count
2
44.1
bone density
2
37.3
heel bone mineral density
1
29
handedness
0
1.1
24.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein subunit alpha z
706704
Mouse
MGI:95780
14687
Rat
RGD:2717
25740
Dog
G protein subunit alpha z
VGNC:41310
607445
Horse
G protein subunit alpha z
VGNC:18422
100049992
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein subunit alpha z
Mouse
Rat
Dog
G protein subunit alpha z
Horse
G protein subunit alpha z
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19086-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
G alpha (z) signalling events
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G alpha (i) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (211)
1 – 10 of 211
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999985447
p_ni:  0.000014553
Data Source:  BioPlex
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.9998674
p_ni:  0.000132352
p_wrong:  2.48e-7
Score:  0.969
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.99887041
p_ni:  0.001129587
p_wrong:  3e-9
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.998376048
p_ni:  0.00162395
p_wrong:  2e-9
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.997985985
p_ni:  0.002014013
p_wrong:  3e-9
Data Source:  BioPlex
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.997345137
p_ni:  0.002644545
p_wrong:  0.000010319
Score:  0.945
Data Source:  BioPlex,Reactome,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.990397588
p_ni:  0.009598485
p_wrong:  0.000003927
Score:  0.307
Data Source:  BioPlex,STRINGDB
HBG2
Tbio
Novelty:  0.01145628
p_int:  0.985125023
p_ni:  0.01486951
p_wrong:  0.000005467
Data Source:  BioPlex
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.980300489
p_ni:  0.019699499
p_wrong:  1.2e-8
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.977486468
p_ni:  0.022513449
p_wrong:  8.3e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  49.57

PubMed score by year
PubTator Score  48.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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