You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TSPAN8
Tetraspanin-8

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247829
  • ENSP00000247829
  • ENSG00000127324
  • ENST00000393330
  • ENSP00000377003
  • ENST00000546561
  • ENSP00000447160

Symbol
  • TM4SF3
  • CO-029
  • TM4SF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
gene perturbation
0.85
PubMedID
0.85
disease perturbation
0.74
small molecule perturbation
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.76   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.76   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
7
3
1.1
89.3
balding measurement
1
1
1
56
1
1
0
1
33.1
sex hormone-binding globulin measurement
1
1
1
24.5
Inhalant adrenergic use measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
89.3
balding measurement
1
56
0
1
33.1
sex hormone-binding globulin measurement
1
24.5
Inhalant adrenergic use measurement
1
21.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 8
VGNC:13485
743174
Macaque
tetraspanin 8
718622
Mouse
MGI:2384918
216350
Rat
RGD:621783
171048
Dog
tetraspanin 8
VGNC:47925
474448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 8
Macaque
tetraspanin 8
Mouse
Rat
Dog
tetraspanin 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19075-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (788)
Items per page:
1 – 5 of 788
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Extracellular vesicle-mediated signaling in recipient cells
WikiPathways
Extracellular vesicle-mediated signaling in recipient cells
WikiPathways
Extracellular vesicle-mediated signaling in recipient cells
WikiPathways
Extracellular vesicle-mediated signaling in recipient cells
WikiPathways
Extracellular vesicle-mediated signaling in recipient cells
Name
Explore in Pharos
Explore in Source
Extracellular vesicle-mediated signaling in recipient cells
Extracellular vesicle-mediated signaling in recipient cells
Extracellular vesicle-mediated signaling in recipient cells
Extracellular vesicle-mediated signaling in recipient cells
Extracellular vesicle-mediated signaling in recipient cells
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (72)
1 – 10 of 72
CDC123
Tbio
Novelty:  0.05599841
Score:  0.763
Data Source:  STRINGDB
THADA
Tbio
Novelty:  0.06983966
Score:  0.74
Data Source:  STRINGDB
JAZF1
Tbio
Novelty:  0.01639328
Score:  0.737
Data Source:  STRINGDB
CAMK1D
Tchem
Family:  Kinase
Novelty:  0.0274233
Score:  0.711
Data Source:  STRINGDB
ADAMTS9
Tbio
Family:  Enzyme
Novelty:  0.01447959
Score:  0.71
Data Source:  STRINGDB
CDKAL1
Tbio
Family:  Enzyme
Novelty:  0.01013607
Score:  0.705
Data Source:  STRINGDB
IGF2BP2
Tbio
Novelty:  0.0105554
Score:  0.675
Data Source:  STRINGDB
WFS1
Tbio
Novelty:  0.00327137
Score:  0.67
Data Source:  STRINGDB
SLC30A8
Tbio
Family:  Transporter
Novelty:  0.00384775
Score:  0.67
Data Source:  STRINGDB
TCF7L2
Tbio
Family:  TF
Novelty:  0.00178694
Score:  0.658
Data Source:  STRINGDB
Publication Statistics
PubMed Score  81.76

PubMed score by year
PubTator Score  41.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer