Tbio CDH2 Cadherin-2

Protein Summary

Description

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P19022
• A8MWK3
• B0YIY6
• Q14923
• Q8N173

Gene Name

• CDH2

Ensembl ID

• ENST00000269141
• ENSP00000269141
• ENSG00000170558
• ENST00000399380
• ENSP00000382312

Symbol

• CDHN
• NCAD
• CDHN
• NCAD
• CD325
• CDw325

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	0.94
protein domain	0.92
disease	0.86
virus perturbation	0.85

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.13   (req: < 5)

Gene RIFs: 229   (req: <= 3)

Antibodies: 1516   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.13   (req: >= 5)

Gene RIFs: 229   (req: > 3)

Antibodies: 1516   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (472)

Explore Interacting Targets

1 – 10 of 472

• See Interactions on String-DB

CTNNA3

Tbio

Novelty:  0.01472452

p_int:  0.992033066

p_ni:  0.007966931

p_wrong:  3e-9

Score:  0.576

Data Source:  BioPlex,STRINGDB

TAX1BP3

Tbio

Novelty:  0.01605171

p_int:  0.95758017

p_ni:  0.04241983

Data Source:  BioPlex

JUP

Tbio

Novelty:  0.0081803

Score:  0.994

Data Source:  STRINGDB

CTNNB1

Tchem

Novelty:  0.0000744

Score:  0.994

Data Source:  Reactome,STRINGDB

GJA1

Tbio

Novelty:  0.00021332

Score:  0.99

Data Source:  STRINGDB

CTNNA1

Tbio

Novelty:  0.00925774

Score:  0.989

Data Source:  Reactome,STRINGDB

CTNND1

Tbio

Novelty:  0.00335459

Score:  0.983

Data Source:  STRINGDB

FN1

Tchem

Novelty:  0.00003647

Score:  0.981

Data Source:  STRINGDB

FGFR1

Tclin

Family:  Kinase

Novelty:  0.00055714

Score:  0.979

Data Source:  STRINGDB

AXIN1

Tbio

Novelty:  0.00175842

Score:  0.975

Data Source:  STRINGDB

Pathways (81)

Reactome (10)

KEGG (2)

PathwayCommons (8)

WikiPathways (61)

Adherens junctions interactions (R-HSA-418990)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Developmental Biology	1055 targets	R-HSA-1266738

Gene Ontology Terms (64)

Functions (9)

Components (24)

Processes (31)

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1 – 9 of 9

GO Term	Evidence	Assigned by
alpha-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
beta-catenin binding	Inferred from Physical Interaction (IPI)	UniProtKB
gamma-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein phosphatase binding	Inferred from Electronic Annotation (IEA)	Ensembl

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2	2	2		65.3
self reported educational attainment	EFO_0004784	1	1	1		64
optic disc size measurement	EFO_0004832	1	1	1		53.3
daytime rest measurement	EFO_0007828	1	1	1		49.5
cognitive function measurement	EFO_0008354	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2		65.3
self reported educational attainment	EFO_0004784	1		64
optic disc size measurement	EFO_0004832	1		53.3
daytime rest measurement	EFO_0007828	1		49.5
cognitive function measurement	EFO_0008354	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Membrane
Metal-binding

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
daytime rest measurement
household income
intelligence
mathematical ability
optic disc size measurement
refractive error measurement
self reported educational attainment
urinary albumin to creatinine ratio

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cadherin 2	VGNC:7314	468509
Macaque	cadherin 2		711526
Mouse	cadherin 2	MGI:88355	12558
Rat	cadherin 2	RGD:69280	83501
Dog	cadherin 2	VGNC:39028	480169

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cadherin 2
Macaque	cadherin 2
Mouse	cadherin 2
Rat	cadherin 2
Dog	cadherin 2

Publication Statistics

PubMed Score 2302.13

PubMed score by year

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PubTator Score 1246.21

PubTator score by year

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