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Tbio
CDH2
Cadherin-2

Protein Summary
Description
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269141
  • ENSP00000269141
  • ENSG00000170558
  • ENST00000399380
  • ENSP00000382312

Symbol
  • CDHN
  • NCAD
  • CDHN
  • NCAD
  • CD325
  • CDw325
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.94
protein domain
0.92
disease
0.86
virus perturbation
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.13   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 1516   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.13   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 1516   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (472)
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.992033066
p_ni:  0.007966931
p_wrong:  3e-9
Score:  0.576
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.95758017
p_ni:  0.04241983
Data Source:  BioPlex
JUP
Tbio
Novelty:  0.0081803
Score:  0.994
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.994
Data Source:  Reactome,STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.99
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.989
Data Source:  Reactome,STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.983
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.981
Data Source:  STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.979
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (81)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (64)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
65.3
self reported educational attainment
1
1
1
64
optic disc size measurement
1
1
1
53.3
daytime rest measurement
1
1
1
49.5
cognitive function measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
65.3
self reported educational attainment
1
64
optic disc size measurement
1
53.3
daytime rest measurement
1
49.5
cognitive function measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 2
VGNC:7314
468509
Macaque
cadherin 2
711526
Mouse
MGI:88355
12558
Rat
RGD:69280
83501
Dog
cadherin 2
VGNC:39028
480169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 2
Macaque
cadherin 2
Mouse
Rat
Dog
cadherin 2
Publication Statistics
PubMed Score 2302.13
PubMed score by year
PubTator Score 1246.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title