Protein Summary
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the for ...more
- ENST00000269141
- ENSP00000269141
- ENSG00000170558
- ENST00000399380
- ENSP00000382312
- CDHN
- NCAD
- CDHN
- NCAD
- CD325
- CDw325
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 0.94 | ||
protein domain | 0.92 | ||
disease | 0.86 | ||
virus perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2302.13 (req: < 5)
Gene RIFs: 229 (req: <= 3)
Antibodies: 1516 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2302.13 (req: >= 5)
Gene RIFs: 229 (req: > 3)
Antibodies: 1516 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (472)
CTNNA3
Novelty: 0.01472452
p_int: 0.992033066
p_ni: 0.007966931
p_wrong: 3e-9
Score: 0.576
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (81)
Reactome (10)
KEGG (2)
PathwayCommons (8)
WikiPathways (61)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (9)
Components (24)
Processes (31)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 2 | 2 | 65.3 | |||||
self reported educational attainment | 1 | 1 | 1 | 64 | |||||
optic disc size measurement | 1 | 1 | 1 | 53.3 | |||||
daytime rest measurement | 1 | 1 | 1 | 49.5 | |||||
cognitive function measurement | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 65.3 | |||||
self reported educational attainment | 1 | 64 | |||||
optic disc size measurement | 1 | 53.3 | |||||
daytime rest measurement | 1 | 49.5 | |||||
cognitive function measurement | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cadherin 2 | VGNC:7314 | 468509 | |||||
Macaque | cadherin 2 | 711526 | ||||||
Mouse | MGI:88355 | 12558 | ||||||
Rat | RGD:69280 | 83501 | ||||||
Dog | cadherin 2 | VGNC:39028 | 480169 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cadherin 2 | |||||
Macaque | cadherin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cadherin 2 | |||||
Publication Statistics
PubMed Score 2302.13
PubMed score by year
PubTator Score 1246.21
PubTator score by year
Related Publications
Text Mined References (290)
GeneRif Annotations (229)
Items per page:
0 of 0
PMID | Year | Title |
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