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Tbio
KRT4
Keratin, type II cytoskeletal 4

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293774
  • ENSP00000293774
  • ENSG00000170477
  • ENST00000551956
  • ENSP00000448220

Symbol
  • CYK4
  • K4
  • CK4
  • CK-4
  • CYK4
  • WSN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
gene perturbation
0.73
tissue
0.63
disease
0.54
small molecule perturbation
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.58   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.58   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
KRT13
Tbio
Novelty:  0.00468754
Score:  0.961
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.945
Data Source:  STRINGDB
KRT16
Tbio
Novelty:  0.00503235
Score:  0.943
Data Source:  STRINGDB
KRT15
Tbio
Novelty:  0.00351898
Score:  0.94
Data Source:  STRINGDB
KRT19
Tbio
Novelty:  0.00043162
Score:  0.938
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.937
Data Source:  STRINGDB
KRT18
Tbio
Novelty:  0.00069055
Score:  0.935
Data Source:  STRINGDB
KRT9
Tbio
Novelty:  0.00787691
Score:  0.933
Data Source:  STRINGDB
KRT28
Tdark
Novelty:  0.48119283
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
82.7
1
1
0
1.6
59.5
serum alanine aminotransferase measurement
1
1
0
5.7
24.5
aspartate aminotransferase measurement
2
1
1
6.3
9.5
bilirubin measurement
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
82.7
0
1.6
59.5
serum alanine aminotransferase measurement
0
5.7
24.5
aspartate aminotransferase measurement
1
6.3
9.5
bilirubin measurement
1
5.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 4
VGNC:8449
466999
Macaque
keratin 4
700060
Mouse
MGI:96701
16682
Rat
RGD:1359272
315323
Dog
keratin 71
486522
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 4
Macaque
keratin 4
Mouse
Rat
Dog
keratin 71
Publication Statistics
PubMed Score 218.58
PubMed score by year
PubTator Score 181.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title