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Tbio
KRT15
Keratin, type I cytoskeletal 15

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254043
  • ENSP00000254043
  • ENSG00000171346
  • ENST00000393976
  • ENSP00000377546

Symbol
  • KRTB
  • K15
  • CK15
  • K1CO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
small molecule perturbation
0.81
interacting protein
0.74
cell type or tissue
0.71
disease
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.45   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 816   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.45   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 816   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 15
VGNC:9352
100611264
Mouse
MGI:96689
16665
Rat
RGD:1303044
287700
Dog
keratin 15
VGNC:42518
100685404
Cow
keratin 15
VGNC:50396
507464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 15
Mouse
Rat
Dog
keratin 15
Cow
keratin 15
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P19012-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (77)
1 – 10 of 77
KRT5
Tbio
Novelty: 0.00072336
Score: 0.956
Data Source: STRINGDB
KRT13
Tbio
Novelty: 0.00468754
Score: 0.952
Data Source: STRINGDB
KRT1
Tbio
Novelty: 0.00278467
Score: 0.947
Data Source: STRINGDB
KRT6B
Tbio
Novelty: 0.00152754
Score: 0.944
Data Source: STRINGDB
KRT6A
Tbio
Novelty: 0.00789111
Score: 0.941
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00434637
Score: 0.94
Data Source: STRINGDB
KRT80
Tbio
Novelty: 0.08480792
Score: 0.938
Data Source: STRINGDB
KRT8
Tbio
Novelty: 0.00093008
Score: 0.936
Data Source: STRINGDB
KRT6C
Tbio
Novelty: 0.11659743
Score: 0.935
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00039796
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  264.45

PubMed score by year
PubTator Score  169.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer