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Tbio
XRCC1
DNA repair protein XRCC1

Protein Summary
Description
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262887
  • ENSP00000262887
  • ENSG00000073050

Symbol
  • RCC
  • SCAR26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus
0.89
disease
0.83
disease perturbation
0.83
histone modification site profile
0.83
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1268.24   (req: < 5)
Gene RIFs: 752   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1268.24   (req: >= 5)
Gene RIFs: 752   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
46.9
apolipoprotein B measurement
1
1
1
37.8
body height
1
1
1
21.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
46.9
apolipoprotein B measurement
1
37.8
body height
1
21.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-ray repair cross complementing 1
VGNC:11479
456094
Macaque
X-ray repair cross complementing 1
711457
Mouse
MGI:99137
22594
Rat
RGD:619823
84495
Dog
X-ray repair cross complementing 1
VGNC:54004
476447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-ray repair cross complementing 1
Macaque
X-ray repair cross complementing 1
Mouse
Rat
Dog
X-ray repair cross complementing 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18887-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Base Excision Repair
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Gap-filling DNA repair synthesis and ligation in GG-NER
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision Repair
DNA Double-Strand Break Repair
DNA Repair
Gap-filling DNA repair synthesis and ligation in GG-NER
Protein-Protein Interactions (208)
1 – 10 of 208
POLB
Tchem
Family: Enzyme
Novelty: 0.00145102
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
APLF
Tbio
Novelty: 0.01347476
p_int: 0.999996794
p_ni: 0.000003205
p_wrong: 2e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999298296
p_ni: 0.000701672
p_wrong: 3.1e-8
Score: 0.224
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.997229628
p_ni: 0.002770372
Data Source: BioPlex
CHD1L
Tbio
Family: Enzyme
Novelty: 0.00980287
p_int: 0.996704819
p_ni: 0.00329517
p_wrong: 1.1e-8
Score: 0.887
Data Source: BioPlex,STRINGDB
DLX6
Tbio
Family: TF
Novelty: 0.01455012
p_int: 0.987482047
p_ni: 0.012516865
p_wrong: 0.000001088
Data Source: BioPlex
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.983130941
p_ni: 0.016774587
p_wrong: 0.000094473
Score: 0.309
Data Source: BioPlex,STRINGDB
PCDHB11
Tdark
Novelty: 0.80480462
p_int: 0.981657504
p_ni: 0.018342495
Data Source: BioPlex
XRCC6
Tbio
Novelty: 0.00127955
p_int: 0.977497961
p_ni: 0.022502039
p_wrong: 1e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.965138336
p_ni: 0.034857135
p_wrong: 0.000004528
Data Source: BioPlex
Publication Statistics
PubMed Score  1268.24

PubMed score by year
PubTator Score  860.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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