Tchem LIG1 DNA ligase 1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Ligase / Dna Ligase 1

Protein / Ligase / Dna Ligase / Dna Ligase 1

DTO Classes

Protein / Enzyme / Ligase / Dna Ligase / Dna Ligase 1

Protein Summary

Description

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P18858
• B2RAI8
• B4DTU4
• Q2TB12
• Q32P23

Gene Name

• LIG1

Ensembl ID

• ENST00000263274
• ENSP00000263274
• ENSG00000105486
• ENST00000427526
• ENSP00000442841
• ENST00000601091
• ENSP00000471836
• ENST00000613670
• ENSP00000483027

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
ligand (protein) perturbation	0.99
histone modification site profile	0.93
molecular function	0.93
protein domain	0.85

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.48   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.48   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL468590

LIG1Tchem Enzyme

IC50: 6.22

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (45)

Reactome (32)

KEGG (4)

WikiPathways (9)

Base Excision Repair (R-HSA-73884)

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Items per page:

5

1 – 5 of 32

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Base Excision Repair	72 targets	R-HSA-73884
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Chromosome Maintenance	88 targets	R-HSA-73886
Reactome	DNA Repair	306 targets	R-HSA-73894

Name	Explore in Pharos	Explore in Source
Base Excision Repair	72 targets	R-HSA-73884
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Chromosome Maintenance	88 targets	R-HSA-73886
DNA Repair	306 targets	R-HSA-73894

Gene Ontology Terms (23)

Functions (5)

Components (5)

Processes (13)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
DNA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
DNA ligase (ATP) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (329)

Explore Interacting Targets

1 – 10 of 329

• See Interactions on String-DB

RNF166

Tdark

Novelty: 0.66985646

p_int: 0.999998636

p_ni: 0.000001297

p_wrong: 6.7e-8

Score: 0.34

Data Source: BioPlex,STRINGDB

PCNA

Tchem

Novelty: 0.00995674

Score: 0.999

Data Source: Reactome,STRINGDB

FEN1

Tchem

Family: Enzyme

Novelty: 0.00147856

Score: 0.999

Data Source: STRINGDB

POLD1

Tclin

Family: Enzyme

Novelty: 0.00751863

Score: 0.996

Data Source: Reactome,STRINGDB

POLE

Tclin

Family: Enzyme

Novelty: 0.00492007

Score: 0.996

Data Source: STRINGDB

RFC4

Tbio

Novelty: 0.05335859

Score: 0.992

Data Source: STRINGDB

APEX1

Tchem

Family: Enzyme

Novelty: 0.00035132

Score: 0.988

Data Source: Reactome,STRINGDB

RFC1

Tbio

Novelty: 0.0408089

Score: 0.987

Data Source: STRINGDB

RFC5

Tbio

Novelty: 0.07603566

Score: 0.986

Data Source: STRINGDB

RPA1

Tchem

Novelty: 0.00309278

Score: 0.984

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  261.48

PubMed score by year

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PubTator Score  46.7

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE

1-70

EDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ

70-140

SEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQE

140-210

LQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDAC

210-280

WKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVG

280-350

DGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST

350-420

AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAE

420-490

ARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE

490-560

AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKK

560-630

QIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLD

630-700

TKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGK

700-770

RAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA

770-840

VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGED

840-910

SGSDPEDTY

910-919

MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY

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Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
ATP-binding
Cell cycle
Cell division
Complete proteome
DNA damage
DNA recombination
DNA repair