Protein Summary
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000263274
- ENSP00000263274
- ENSG00000105486
- ENST00000427526
- ENSP00000442841
- ENST00000601091
- ENSP00000471836
- ENST00000613670
- ENSP00000483027
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
ligand (protein) perturbation | 0.99 | ||
histone modification site profile | 0.93 | ||
molecular function | 0.93 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 295.31 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 492 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 295.31 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 492 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0