Protein Classes
Protein Summary
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000263274
- ENSP00000263274
- ENSG00000105486
- ENST00000427526
- ENSP00000442841
- ENST00000601091
- ENSP00000471836
- ENST00000613670
- ENSP00000483027
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 0.99 | ||
ligand (protein) perturbation | 0.99 | ||
histone modification site profile | 0.93 | ||
molecular function | 0.93 | ||
protein domain | 0.85 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.48 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 492 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.48 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 492 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (45)
Reactome (32)
KEGG (4)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 32
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Base Excision Repair | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | DNA Repair | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Base Excision Repair | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromosome Maintenance | ||||
DNA Repair | ||||
Gene Ontology Terms (23)
Functions (5)
Components (5)
Processes (13)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (329)
1 – 10 of 329
RNF166
Novelty: 0.66985646
p_int: 0.999998636
p_ni: 0.000001297
p_wrong: 6.7e-8
Score: 0.34
Data Source: BioPlex,STRINGDB
PCNA
Novelty: 0.00995674
Score: 0.999
Data Source: Reactome,STRINGDB
FEN1
Family: Enzyme
Novelty: 0.00147856
Score: 0.999
Data Source: STRINGDB
POLD1
Family: Enzyme
Novelty: 0.00751863
Score: 0.996
Data Source: Reactome,STRINGDB
POLE
Family: Enzyme
Novelty: 0.00492007
Score: 0.996
Data Source: STRINGDB
RFC4
Novelty: 0.05335859
Score: 0.992
Data Source: STRINGDB
APEX1
Family: Enzyme
Novelty: 0.00035132
Score: 0.988
Data Source: Reactome,STRINGDB
RFC1
Novelty: 0.0408089
Score: 0.987
Data Source: STRINGDB
RFC5
Novelty: 0.07603566
Score: 0.986
Data Source: STRINGDB
RPA1
Novelty: 0.00309278
Score: 0.984
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 261.48
PubMed score by year
PubTator Score 46.7
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE
1-70
EDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ
70-140
SEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQE
140-210
LQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDAC
210-280
WKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVG
280-350
DGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
350-420
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAE
420-490
ARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
490-560
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKK
560-630
QIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLD
630-700
TKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGK
700-770
RAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
770-840
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGED
840-910
SGSDPEDTY
910-919
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY
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