Protein Classes
Protein Summary
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000263274
- ENSP00000263274
- ENSG00000105486
- ENST00000427526
- ENSP00000442841
- ENST00000601091
- ENSP00000471836
- ENST00000613670
- ENSP00000483027
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
ligand (protein) perturbation | 0.99 | ||
histone modification site profile | 0.93 | ||
molecular function | 0.93 | ||
protein domain | 0.85 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.87 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 492 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.87 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 492 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA ligase 1 | VGNC:10202 | 468936 | |||||
Macaque | DNA ligase 1 | 718528 | ||||||
Mouse | MGI:101789 | 16881 | ||||||
Rat | RGD:6491367 | 100911727 | ||||||
Dog | DNA ligase 1 | VGNC:42673 | 100686967 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA ligase 1 | |||||
Macaque | DNA ligase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA ligase 1 | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (45)
Reactome (32)
KEGG (4)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 32
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Base Excision Repair | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | DNA Repair | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Base Excision Repair | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromosome Maintenance | ||||
DNA Repair | ||||
Gene Ontology Terms (23)
Functions (5)
Components (5)
Processes (13)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (329)
1 – 10 of 329
RNF166
Novelty: 0.71460884
p_int: 0.999998636
p_ni: 0.000001297
p_wrong: 6.7e-8
Score: 0.34
Data Source: BioPlex,STRINGDB
PCNA
Novelty: 0.03909539
Score: 0.999
Data Source: Reactome,STRINGDB
FEN1
Family: Enzyme
Novelty: 0.00082515
Score: 0.999
Data Source: STRINGDB
POLD1
Family: Enzyme
Novelty: 0.00508209
Score: 0.996
Data Source: Reactome,STRINGDB
POLE
Family: Enzyme
Novelty: 0.00371129
Score: 0.996
Data Source: STRINGDB
RFC4
Novelty: 0.03232586
Score: 0.992
Data Source: STRINGDB
APEX1
Family: Enzyme
Novelty: 0.00037532
Score: 0.988
Data Source: Reactome,STRINGDB
RFC1
Novelty: 0.02642014
Score: 0.987
Data Source: STRINGDB
RFC5
Novelty: 0.03987481
Score: 0.986
Data Source: STRINGDB
RPA1
Novelty: 0.00212665
Score: 0.984
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 285.87
PubMed score by year
PubTator Score 46.7
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword