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Tchem
LIG1
DNA ligase 1

Protein Summary
Description
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263274
  • ENSP00000263274
  • ENSG00000105486
  • ENST00000427526
  • ENSP00000442841
  • ENST00000601091
  • ENSP00000471836
  • ENST00000613670
  • ENSP00000483027
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
ligand (protein) perturbation
0.99
histone modification site profile
0.93
molecular function
0.93
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.71   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.71   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
46.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA ligase 1
VGNC:10202
468936
Macaque
DNA ligase 1
718528
Mouse
MGI:101789
16881
Rat
RGD:6491367
100911727
Dog
DNA ligase 1
VGNC:42673
100686967
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA ligase 1
Macaque
DNA ligase 1
Mouse
Rat
Dog
DNA ligase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Repair
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (329)
1 – 10 of 329
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.999998636
p_ni:  0.000001297
p_wrong:  6.7e-8
Score:  0.34
Data Source:  BioPlex,STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.999
Data Source:  Reactome,STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
Score:  0.999
Data Source:  STRINGDB
POLD1
Tclin
Family:  Enzyme
Novelty:  0.00508209
Score:  0.996
Data Source:  Reactome,STRINGDB
POLE
Tclin
Family:  Enzyme
Novelty:  0.00371129
Score:  0.996
Data Source:  STRINGDB
RFC4
Tbio
Novelty:  0.03232586
Score:  0.992
Data Source:  STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.988
Data Source:  Reactome,STRINGDB
RFC1
Tbio
Novelty:  0.02642014
Score:  0.987
Data Source:  STRINGDB
RFC5
Tbio
Novelty:  0.03987481
Score:  0.986
Data Source:  STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.984
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  285.71

PubMed score by year
PubTator Score  46.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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