Tchem LIG1 DNA ligase 1

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Ligase / Dna Ligase 1

Protein / Ligase / Dna Ligase / Dna Ligase 1

DTO Classes

Protein / Enzyme / Ligase / Dna Ligase / Dna Ligase 1

Protein Summary

Description

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P18858
• B2RAI8
• B4DTU4
• Q2TB12
• Q32P23

Gene Name

• LIG1

Ensembl ID

• ENST00000263274
• ENSP00000263274
• ENSG00000105486
• ENST00000427526
• ENSP00000442841
• ENST00000601091
• ENSP00000471836
• ENST00000613670
• ENSP00000483027

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
ligand (protein) perturbation	0.99
histone modification site profile	0.93
molecular function	0.93
protein domain	0.85

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.71   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.71   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

CHEMBL2348305

LIG1Tchem Enzyme

IC50 : 6

CHEMBL468590

LIG1Tchem Enzyme

IC50 : 6.22

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
refractive error measurement	EFO_0007814	1	1	1		46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
refractive error measurement	EFO_0007814	1		46.1

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	DNA ligase 1	VGNC:10202	468936
Macaque	DNA ligase 1		718528
Mouse	ligase I, DNA, ATP-dependent	MGI:101789	16881
Rat	DNA ligase 1-like	RGD:6491367	100911727
Dog	DNA ligase 1	VGNC:42673	100686967

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DNA ligase 1
Macaque	DNA ligase 1
Mouse	ligase I, DNA, ATP-dependent
Rat	DNA ligase 1-like
Dog	DNA ligase 1

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (45)

Reactome (32)

KEGG (4)

WikiPathways (9)

Base Excision Repair (R-HSA-73884)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Base Excision Repair	72 targets	R-HSA-73884
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Chromosome Maintenance	88 targets	R-HSA-73886
Reactome	DNA Repair	306 targets	R-HSA-73894

Name	Explore in Pharos	Explore in Source
Base Excision Repair	72 targets	R-HSA-73884
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Chromosome Maintenance	88 targets	R-HSA-73886
DNA Repair	306 targets	R-HSA-73894

Gene Ontology Terms (23)

Functions (5)

Components (5)

Processes (13)

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1 – 5 of 5

GO Term	Evidence	Assigned by
DNA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
DNA ligase (ATP) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (329)

Explore Interacting Targets

1 – 10 of 329

• See Interactions on String-DB

RNF166

Tdark

Novelty:  0.71460884

p_int:  0.999998636

p_ni:  0.000001297

p_wrong:  6.7e-8

Score:  0.34

Data Source:  BioPlex,STRINGDB

PCNA

Tchem

Novelty:  0.03909539

Score:  0.999

Data Source:  Reactome,STRINGDB

FEN1

Tchem

Family:  Enzyme

Novelty:  0.00082515

Score:  0.999

Data Source:  STRINGDB

POLD1

Tclin

Family:  Enzyme

Novelty:  0.00508209

Score:  0.996

Data Source:  Reactome,STRINGDB

POLE

Tclin

Family:  Enzyme

Novelty:  0.00371129

Score:  0.996

Data Source:  STRINGDB

RFC4

Tbio

Novelty:  0.03232586

Score:  0.992

Data Source:  STRINGDB

APEX1

Tchem

Family:  Enzyme

Novelty:  0.00037532

Score:  0.988

Data Source:  Reactome,STRINGDB

RFC1

Tbio

Novelty:  0.02642014

Score:  0.987

Data Source:  STRINGDB

RFC5

Tbio

Novelty:  0.03987481

Score:  0.986

Data Source:  STRINGDB

RPA1

Tchem

Novelty:  0.00212665

Score:  0.984

Data Source:  Reactome,STRINGDB

Publication Statistics

PubMed Score  285.71

PubMed score by year

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PubTator Score  46.7

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
ATP-binding
Cell cycle
Cell division
Complete proteome
DNA damage
DNA recombination
DNA repair

GWAS Trait Find Similar Targets

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refractive error measurement

MGI Phenotype Find Similar Targets

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cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging