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Tbio
ATF6
Cyclic AMP-dependent transcription factor ATF-6 alpha

Protein Summary
Description
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367942
  • ENSP00000356919
  • ENSG00000118217

Symbol
  • ACHM7
  • ATF6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.98
trait
0.97
transcription factor binding site profile
0.91
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.96   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 571   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.96   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 571   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
3
87.7
hemoglobin measurement
1
1
1
19.3
erythrocyte count
1
1
1
19.3
hematocrit
1
1
1
19.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
87.7
hemoglobin measurement
1
19.3
erythrocyte count
1
19.3
hematocrit
1
19.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 6
VGNC:52942
457461
Macaque
activating transcription factor 6
720056
Mouse
MGI:1926157
226641
Rat
RGD:1305471
304962
Dog
activating transcription factor 6
VGNC:38212
488660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 6
Macaque
activating transcription factor 6
Mouse
Rat
Dog
activating transcription factor 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P18850-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
Metabolism of proteins
PERK regulates gene expression
Gene Ontology Terms (34)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (205)
1 – 10 of 205
RARRES1
Tbio
Family: Enzyme
Novelty: 0.04701793
p_int: 0.99494895
p_ni: 0.00505105
Data Source: BioPlex
IL7
Tbio
Novelty: 0.00054101
p_int: 0.994302625
p_ni: 0.005697375
Data Source: BioPlex
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.96825875
p_ni: 0.03174125
Data Source: BioPlex
PCDH20
Tbio
Novelty: 0.07862843
p_int: 0.966337095
p_ni: 0.033662905
Data Source: BioPlex
ERLEC1
Tbio
Novelty: 0.01243855
p_int: 0.959231743
p_ni: 0.040768257
Score: 0.345
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.957749501
p_ni: 0.042250499
Score: 0.169
Data Source: BioPlex,STRINGDB
PCDHGC5
Tdark
Novelty: 0.39651826
p_int: 0.911160593
p_ni: 0.088839407
Data Source: BioPlex
CD160
Tbio
Novelty: 0.01511748
p_int: 0.902668658
p_ni: 0.097331342
Data Source: BioPlex
PCDHAC1
Tdark
Novelty: 0.3734734
p_int: 0.89356635
p_ni: 0.10643365
Score: 0.19
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.891038312
p_ni: 0.108961688
Score: 0.441
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  670.96

PubMed score by year
PubTator Score  297.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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