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Tbio
ATF4
Cyclic AMP-dependent transcription factor ATF-4

Protein Summary
Description
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337304
  • ENSP00000336790
  • ENSG00000128272
  • ENST00000396680
  • ENSP00000379912
  • ENST00000404241
  • ENSP00000384587

Symbol
  • CREB2
  • TXREB
  • CREB2
  • TXREB
  • CREB-2
  • TAXREB67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
biological process
0.98
molecular function
0.98
transcription factor binding site profile
0.98
kinase perturbation
0.95


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.7   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 1011   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.7   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 1011   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 4
VGNC:5227
744513
Mouse
MGI:88096
11911
Rat
RGD:621863
79255
Dog
activating transcription factor 4
VGNC:38210
474503
Horse
activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 4
Mouse
Rat
Dog
activating transcription factor 4
Horse
activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18848-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (320)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
Metabolism of proteins
PERK regulates gene expression
Gene Ontology Terms (64)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (258)
1 – 10 of 258
TBC1D25
Tbio
Novelty: 0.06756361
p_int: 0.999994505
p_ni: 0.000005495
Score: 0.689
Data Source: BioPlex,STRINGDB
DDIT3
Tbio
Novelty: 0.00116135
Score: 0.996
Data Source: STRINGDB
DDIT3
Tchem
Family: TF
Novelty: 0.00116135
Score: 0.996
Data Source: STRINGDB
ATF3
Tbio
Family: TF
Novelty: 0.00164508
Score: 0.995
Data Source: STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.991
Data Source: STRINGDB
PPP1R15A
Tbio
Family: Enzyme
Novelty: 0.00529607
Score: 0.989
Data Source: STRINGDB
XBP1
Tchem
Family: TF
Novelty: 0.00095584
Score: 0.988
Data Source: STRINGDB
ASNS
Tchem
Family: Enzyme
Novelty: 0.00337445
Score: 0.986
Data Source: STRINGDB
EIF2AK3
Tchem
Family: Kinase
Novelty: 0.00044559
Score: 0.983
Data Source: STRINGDB
EIF2S1
Tbio
Novelty: 0.00076124
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  281.70

PubMed score by year
PubTator Score  484.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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