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Tbio
ATF3
Cyclic AMP-dependent transcription factor ATF-3

Protein Summary
Description
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336937
  • ENSP00000336908
  • ENSG00000162772
  • ENST00000341491
  • ENSP00000344352
  • ENST00000366983
  • ENSP00000355950
  • ENST00000366987
  • ENSP00000355954
  • ENST00000464547
  • ENSP00000432208
  • ENST00000613104
  • ENSP00000480606
  • ENST00000613954
  • ENSP00000483576
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
virus perturbation
1
small molecule perturbation
0.99
molecular function
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 770.05   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 770.05   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.999999909
p_ni:  4.9e-8
p_wrong:  4.2e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999993721
p_ni:  3.9e-8
p_wrong:  0.00000624
Data Source:  BioPlex
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.999
Data Source:  STRINGDB
ATF4
Tbio
Family:  TF
Novelty:  0.00253408
Score:  0.995
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.976
Data Source:  STRINGDB
P0DPQ6
Tbio
Novelty:  0.00116135
Score:  0.973
Data Source:  STRINGDB
P35638
Tchem
Family:  TF
Novelty:  0.00116135
Score:  0.973
Data Source:  STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.96
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.938
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Metabolism of proteins
PERK regulates gene expression
Unfolded Protein Response (UPR)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Genetic Interaction (IGI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
15.8
1
1
0
1.1
13.7
lymphocyte percentage of leukocytes
1
1
1
11.6
neutrophil percentage of leukocytes
1
1
1
11.3
Eczema
1
1
0
1.1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
15.8
0
1.1
13.7
lymphocyte percentage of leukocytes
1
11.6
neutrophil percentage of leukocytes
1
11.3
Eczema
0
1.1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 3
VGNC:10546
469143
Macaque
activating transcription factor 3
710832
Mouse
MGI:109384
11910
Rat
RGD:2165
25389
Dog
activating transcription factor 3
VGNC:38209
612911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 3
Macaque
activating transcription factor 3
Mouse
Rat
Dog
activating transcription factor 3
Publication Statistics
PubMed Score 770.05
PubMed score by year
PubTator Score 288.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title