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Tbio
ATF3
Cyclic AMP-dependent transcription factor ATF-3

Protein Summary
Description
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336937
  • ENSP00000336908
  • ENSG00000162772
  • ENST00000341491
  • ENSP00000344352
  • ENST00000366983
  • ENSP00000355950
  • ENST00000366987
  • ENSP00000355954
  • ENST00000464547
  • ENSP00000432208
  • ENST00000613104
  • ENSP00000480606
  • ENST00000613954
  • ENSP00000483576
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
virus perturbation
1
small molecule perturbation
0.99
molecular function
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 847.43   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 847.43   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0