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Tchem
ATF1
Cyclic AMP-dependent transcription factor ATF-1

Protein Summary
Description
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262053
  • ENSP00000262053
  • ENSG00000123268

Symbol
  • TREB36
  • EWS-ATF1
  • FUS/ATF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
transcription factor binding site profile
0.9
histone modification site profile
0.86
kinase perturbation
0.84
kinase
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.53   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.53   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (79)
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999987921
p_ni:  0.000012069
p_wrong:  1e-8
Data Source:  BioPlex
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
p_int:  0.99969949
p_ni:  0.000169783
p_wrong:  0.000130727
Data Source:  BioPlex
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.999668864
p_ni:  0.000118756
p_wrong:  0.00021238
Score:  0.303
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.999653255
p_ni:  0.000290004
p_wrong:  0.000056741
Data Source:  BioPlex
IDO2
Tchem
Family:  Enzyme
Novelty:  0.01141558
p_int:  0.992090097
p_ni:  0.007908501
p_wrong:  0.000001402
Score:  0.161
Data Source:  BioPlex,STRINGDB
CREBRF
Tbio
Novelty:  0.04113605
p_int:  0.991540207
p_ni:  0.00845898
p_wrong:  8.13e-7
Score:  0.39
Data Source:  BioPlex,STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
p_int:  0.963090246
p_ni:  0.000332277
p_wrong:  0.036577477
Score:  0.207
Data Source:  BioPlex,STRINGDB
CACNG2
Tbio
Family:  IC
Novelty:  0.00808502
p_int:  0.934594513
p_ni:  0.000540023
p_wrong:  0.064865464
Score:  0.234
Data Source:  BioPlex,STRINGDB
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.883645156
p_ni:  0.000583193
p_wrong:  0.115771651
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.876195678
p_ni:  0.000489609
p_wrong:  0.123314713
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (44)
CREB phosphorylation (R-HSA-199920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CREB phosphorylation
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-17 signaling
Name
Explore in Pharos
Explore in Source
CREB phosphorylation
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-17 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
96.6
sex hormone-binding globulin measurement
9
2
8
9.9
86
fibrinogen measurement
2
2
2
82.4
1
1
0
1.1
78.6
red blood cell distribution width
2
1
2
73.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
96.6
sex hormone-binding globulin measurement
8
9.9
86
fibrinogen measurement
2
82.4
0
1.1
78.6
red blood cell distribution width
2
73.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 1
VGNC:12788
452429
Mouse
MGI:1298366
11908
Rat
RGD:1307360
315305
Dog
activating transcription factor 1
VGNC:38207
486545
Horse
activating transcription factor 1
VGNC:15609
100060298
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 1
Mouse
Rat
Dog
activating transcription factor 1
Horse
activating transcription factor 1
Publication Statistics
PubMed Score 73.53
PubMed score by year
PubTator Score 161.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title