Protein Summary
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode ...more
- ENST00000254351
- ENSP00000254351
- ENSG00000115884
- ENST00000381150
- ENSP00000370542
- SDC
- SDC
- CD138
- SYND1
- syndecan
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
biological process | 0.91 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2459.47 (req: < 5)
Gene RIFs: 258 (req: <= 3)
Antibodies: 1362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2459.47 (req: >= 5)
Gene RIFs: 258 (req: > 3)
Antibodies: 1362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (320)
FARP1
Novelty: 0.04040696
p_int: 0.999995054
p_ni: 0.000004946
Score: 0.257
Data Source: BioPlex,STRINGDB
DHRS2
Family: Enzyme
Novelty: 0.002032
p_int: 0.999978149
p_ni: 0.000008227
p_wrong: 0.000013624
Score: 0.313
Data Source: BioPlex,STRINGDB
GMEB2
Family: TF
Novelty: 0.1945427
p_int: 0.999970602
p_ni: 0.000028782
p_wrong: 6.16e-7
Score: 0.663
Data Source: BioPlex,STRINGDB
FGF2
Novelty: 0.00007856
p_int: 0.999918517
p_ni: 0.00000195
p_wrong: 0.000079534
Score: 0.981
Data Source: BioPlex,STRINGDB
PRDM10
Family: TF; Epigenetic
Novelty: 0.03463517
p_int: 0.99975567
p_ni: 0.000244327
p_wrong: 3e-9
Score: 0.299
Data Source: BioPlex,STRINGDB
CYHR1
Novelty: 0.04771996
p_int: 0.999722829
p_ni: 0.000275122
p_wrong: 0.000002049
Data Source: BioPlex
EPHA2
Family: Kinase
Novelty: 0.00191002
p_int: 0.998340724
p_ni: 0.001659276
Score: 0.414
Data Source: BioPlex,STRINGDB
CSNK1G3
Family: Kinase
Novelty: 0.07584067
p_int: 0.997757967
p_ni: 0.002242033
Data Source: BioPlex
OCLN
Novelty: 0.00047671
p_int: 0.997355459
p_ni: 0.002644539
p_wrong: 2e-9
Score: 0.267
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (8)
Upstream (7)
Downstream (1)
1 – 5 of 7
Pathways (52)
Reactome (33)
KEGG (5)
PathwayCommons (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Cell surface interactions at the vascular wall | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Cytokine Signaling in Immune system | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (2)
Components (8)
Processes (19)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 87.6 | |||||
apolipoprotein A 1 measurement | 1 | 2 | 2 | 83.7 | |||||
total cholesterol measurement | 2 | 4 | 6 | 82.2 | |||||
testosterone measurement | 3 | 2 | 3 | 82 | |||||
low density lipoprotein cholesterol measurement | 2 | 3 | 3 | 81.4 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 87.6 | |||||
apolipoprotein A 1 measurement | 2 | 83.7 | |||||
total cholesterol measurement | 6 | 82.2 | |||||
testosterone measurement | 3 | 82 | |||||
low density lipoprotein cholesterol measurement | 3 | 81.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | syndecan 1 | 701544 | ||||||
Mouse | MGI:1349162 | 20969 | ||||||
Rat | RGD:3648 | 25216 | ||||||
Dog | syndecan 1 | VGNC:45942 | 482986 | |||||
Horse | syndecan 1 | VGNC:22761 | 100071892 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | syndecan 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syndecan 1 | |||||
Horse | syndecan 1 | |||||
Publication Statistics
PubMed Score 2459.47
PubMed score by year
PubTator Score 1001.13
PubTator score by year
Related Publications
Text Mined References (303)
GeneRif Annotations (258)
Items per page:
0 of 0
PMID | Year | Title |
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