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Tclin
ADRA2C
Alpha-2C adrenergic receptor

Protein Summary
Description
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330055
  • ENSP00000386069
  • ENSG00000184160

Symbol
  • ADRA2L2
  • ADRA2RL2
  • ADRA2L2
  • ADRARL2
  • ADRA2RL2
  • ALPHA2CAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological process
0.96
ligand (chemical)
0.94
molecular function
0.81
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.97   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.97   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 300
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 52
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (52)
clozapine
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chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
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thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
clemastine
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fluphenazine
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lisuride
Rendered image for lisuride
Protein-Protein Interactions (311)
NPY
Tbio
Novelty:  0.00012637
Score:  0.966
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.961
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.956
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.955
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.948
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.943
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.943
Data Source:  STRINGDB
AGTR2
Tchem
Family:  GPCR
Novelty:  0.00064774
Score:  0.942
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.941
Data Source:  STRINGDB
GNG7
Tbio
Novelty:  0.08478455
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Adrenaline signalling through Alpha-2 adrenergic receptor (R-HSA-392023)

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Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline signalling through Alpha-2 adrenergic receptor
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Name
Explore in Pharos
Explore in Source
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
potassium measurement
1
1
1
29.9
creatinine measurement
1
1
1
9.2
blood urea nitrogen measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
potassium measurement
1
29.9
creatinine measurement
1
9.2
blood urea nitrogen measurement
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 2C
465178
Macaque
adrenoceptor alpha 2C
719763
Mouse
MGI:87936
11553
Rat
RGD:2058
24175
Pig
adrenoceptor alpha 2C
733706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 2C
Macaque
adrenoceptor alpha 2C
Mouse
Rat
Pig
adrenoceptor alpha 2C
Publication Statistics
PubMed Score 156.97
PubMed score by year
PubTator Score 93.65
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title