You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RCC1
Regulator of chromosome condensation

Protein Summary
Description
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373831
  • ENSP00000362937
  • ENSG00000180198
  • ENST00000373832
  • ENSP00000362938
  • ENST00000373833
  • ENSP00000362939
  • ENST00000398958
  • ENSP00000381931
  • ENST00000649185
  • ENSP00000497402

Symbol
  • CHC1
  • CHC1
  • RCC1-I
  • SNHG3-RCC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.83
cellular component
0.81
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.74   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.74   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
21.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of chromosome condensation 1
VGNC:1486
100568439
Mouse
MGI:1913989
100088
Rat
RGD:1592835
682908
Dog
regulator of chromosome condensation 1
VGNC:45440
487332
Horse
regulator of chromosome condensation 1
VGNC:22267
100070733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of chromosome condensation 1
Mouse
Rat
Dog
regulator of chromosome condensation 1
Horse
regulator of chromosome condensation 1
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
Host Interactions of HIV factors
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
HIV Life Cycle
Host Interactions of HIV factors
Infectious disease
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (231)
1 – 10 of 231
RGPD8
Tdark
Novelty: 0.12397737
p_int: 0.999999226
p_ni: 7.73e-7
p_wrong: 1e-9
Score: 0.586
Data Source: BioPlex,STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00160888
p_int: 0.999998381
p_ni: 0.000001619
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RGPD5
Tbio
Novelty: 0.13776125
p_int: 0.999997852
p_ni: 0.000002148
Score: 0.479
Data Source: BioPlex,STRINGDB
RGPD3
Tdark
Novelty: 0.66363867
p_int: 0.999985166
p_ni: 0.000014833
Score: 0.743
Data Source: BioPlex,STRINGDB
DLGAP5
Tbio
Novelty: 0.01673312
p_int: 0.999011341
p_ni: 0.000043546
p_wrong: 0.000945113
Score: 0.837
Data Source: BioPlex,STRINGDB
RANBP1
Tbio
Family: Enzyme
Novelty: 0.01208948
p_int: 0.998760058
p_ni: 0.001239942
Score: 0.982
Data Source: BioPlex,STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.00917672
p_int: 0.998526406
p_ni: 0.001473594
Score: 0.997
Data Source: BioPlex,STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
p_int: 0.99787342
p_ni: 0.00212658
Score: 0.957
Data Source: BioPlex,STRINGDB
NAV1
Tbio
Novelty: 0.00444608
p_int: 0.997381244
p_ni: 0.001373996
p_wrong: 0.001244759
Score: 0.228
Data Source: BioPlex,STRINGDB
KPNA4
Tbio
Novelty: 0.01326511
p_int: 0.943666024
p_ni: 0.056333976
Score: 0.976
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  288.74

PubMed score by year
PubTator Score  181.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer