Tbio RCC1 Regulator of chromosome condensation

Protein Summary

Description

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).

Uniprot Accession IDs

• P18754
• Q16269
• Q6NT97

Gene Name

• RCC1

Ensembl ID

• ENST00000373831
• ENSP00000362937
• ENSG00000180198
• ENST00000373832
• ENSP00000362938
• ENST00000373833
• ENSP00000362939
• ENST00000398958
• ENSP00000381931
• ENST00000649185
• ENSP00000497402

Symbol

• CHC1
• CHC1
• RCC1-I
• SNHG3-RCC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.83
cellular component	0.81
hub protein	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.15   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 370   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.15   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0