Tclin LAG3 Lymphocyte activation gene 3 protein

Protein Summary

Description

Involved in lymphocyte activation. Binds to HLA class-II antigens. Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P18627
• A8K7T9
• Q7Z643
• LAG-3

Gene Name

• LAG3

Ensembl ID

• ENST00000203629
• ENSP00000203629
• ENSG00000089692
• ENST00000441671
• ENSP00000413825

Symbol

• FDC
• CD223

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
cell type or tissue	0.83
gene perturbation	0.75
biological process	0.59
PubMedID	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Lymphocyte Activation Gene 3 Protein

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Lymphocyte Activation Gene 3 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.54   (req: < 5)

Gene RIFs: 130   (req: <= 3)

Antibodies: 752   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.54   (req: >= 5)

Gene RIFs: 130   (req: > 3)

Antibodies: 752   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1