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Tbio
RPL17
60S ribosomal protein L17

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000579248
  • ENSP00000462023
  • ENSG00000265681
  • ENST00000579408
  • ENSP00000463842
  • ENST00000580261
  • ENSP00000462385
  • ENST00000581373
  • ENSP00000462944
  • ENST00000618613
  • ENSP00000480555
  • ENST00000618619
  • ENSP00000482577

Symbol
  • L17
  • PD-1
  • RPL23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.97
kinase perturbation
0.95
gene perturbation
0.94
virus perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.63   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.63   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (412)
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.963292725
p_ni:  0.036707273
p_wrong:  2e-9
Score:  0.245
Data Source:  BioPlex,STRINGDB
NAP1L1
Tbio
Novelty:  0.03895314
p_int:  0.956729582
p_ni:  0.043270418
Score:  0.339
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.906391634
p_ni:  0.093608366
Data Source:  BioPlex
SART3
Tbio
Novelty:  0.02353492
p_int:  0.90315376
p_ni:  0.09684624
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.900797868
p_ni:  0.099202132
Data Source:  BioPlex
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.802959409
p_ni:  0.197040591
Score:  0.51
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.775991738
p_ni:  0.224008262
Data Source:  BioPlex
ZNF71
Tbio
Family:  TF
Novelty:  0.24703192
p_int:  0.775991738
p_ni:  0.224008262
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.766270976
p_ni:  0.233729024
Score:  0.201
Data Source:  BioPlex,STRINGDB
RPL32
Tbio
Novelty:  0.00279161
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
8
18
5
99.6
apolipoprotein A 1 measurement
2
5
6
98.9
total cholesterol measurement
6
5
11
98.5
BMI-adjusted hip circumference
2
8
11
92.8
body height
1
1
1
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
5
99.6
apolipoprotein A 1 measurement
6
98.9
total cholesterol measurement
11
98.5
BMI-adjusted hip circumference
11
92.8
body height
1
76.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2448270
319195
Rat
RGD:1303019
291434
Cow
ribosomal protein L17
514046
Xenopus
ribosomal protein L17
XB-GENE-5859417
448653
Zebrafish
ZDB-GENE-030131-8585
336641
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
ribosomal protein L17
Xenopus
ribosomal protein L17
Zebrafish
Publication Statistics
PubMed Score 34.63
PubMed score by year
PubTator Score 41.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title