RPL17
60S ribosomal protein L17
Protein Summary
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]
- ENST00000579248
- ENSP00000462023
- ENSG00000265681
- ENST00000579408
- ENSP00000463842
- ENST00000580261
- ENSP00000462385
- ENST00000581373
- ENSP00000462944
- ENST00000618613
- ENSP00000480555
- ENST00000618619
- ENSP00000482577
- L17
- PD-1
- RPL23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.97 | ||
kinase perturbation | 0.95 | ||
gene perturbation | 0.94 | ||
virus perturbation | 0.88 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.63 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.63 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 12 | 8 | 18 | 5 | 99.6 | ||||
apolipoprotein A 1 measurement | 2 | 5 | 6 | 98.9 | |||||
total cholesterol measurement | 6 | 5 | 11 | 98.5 | |||||
BMI-adjusted hip circumference | 2 | 8 | 11 | 92.8 | |||||
body height | 1 | 1 | 1 | 76.6 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 18 | 5 | 99.6 | ||||
apolipoprotein A 1 measurement | 6 | 98.9 | |||||
total cholesterol measurement | 11 | 98.5 | |||||
BMI-adjusted hip circumference | 11 | 92.8 | |||||
body height | 1 | 76.6 | |||||
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2448270 | 319195 | ||||||
Rat | RGD:1303019 | 291434 | ||||||
Cow | ribosomal protein L17 | 514046 | ||||||
Xenopus | ribosomal protein L17 | XB-GENE-5859417 | 448653 | |||||
Zebrafish | ZDB-GENE-030131-8585 | 336641 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Cow | ribosomal protein L17 | |||||
Xenopus | ribosomal protein L17 | |||||
Zebrafish | ||||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (34)
Reactome (32)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 32
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Eukaryotic Translation Elongation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Eukaryotic Translation Elongation | ||||
Gene Ontology Terms (10)
Functions (2)
Components (3)
Processes (5)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (412)
1 – 10 of 412
ZC3HAV1
Novelty: 0.01357759
p_int: 0.963292725
p_ni: 0.036707273
p_wrong: 2e-9
Score: 0.245
Data Source: BioPlex,STRINGDB
NAP1L1
Novelty: 0.03895314
p_int: 0.956729582
p_ni: 0.043270418
Score: 0.339
Data Source: BioPlex,STRINGDB
MAGEB10
Novelty: 2.96156972
p_int: 0.906391634
p_ni: 0.093608366
Data Source: BioPlex
SART3
Novelty: 0.02353492
p_int: 0.90315376
p_ni: 0.09684624
Data Source: BioPlex
DGCR8
Novelty: 0.00271221
p_int: 0.900797868
p_ni: 0.099202132
Data Source: BioPlex
RRS1
Novelty: 0.01643671
p_int: 0.802959409
p_ni: 0.197040591
Score: 0.51
Data Source: BioPlex,STRINGDB
MECP2
Family: TF
Novelty: 0.00051767
p_int: 0.775991738
p_ni: 0.224008262
Data Source: BioPlex
ZNF71
Family: TF
Novelty: 0.24703192
p_int: 0.775991738
p_ni: 0.224008262
Data Source: BioPlex
ZNF2
Family: TF
Novelty: 0.01062543
p_int: 0.766270976
p_ni: 0.233729024
Score: 0.201
Data Source: BioPlex,STRINGDB
RPL32
Novelty: 0.00279161
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 34.63
PubMed score by year
PubTator Score 41.24
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
GWAS Trait
No Header | No Header | ||
|---|---|---|---|