Tbio RPL17 60S ribosomal protein L17

Protein Summary

Description

Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P18621
• B2R4H3
• B4E3C2
• B5ME31
• J3QL51
• Q3KQW2
• Q6NZ54
• Q7M4M5

Gene Name

• RPL17

Ensembl ID

• ENST00000579248
• ENSP00000462023
• ENSG00000265681
• ENST00000579408
• ENSP00000463842
• ENST00000580261
• ENSP00000462385
• ENST00000581373
• ENSP00000462944
• ENST00000618613
• ENSP00000480555
• ENST00000618619
• ENSP00000482577

Symbol

• L17
• PD-1
• RPL23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.97
kinase perturbation	0.95
gene perturbation	0.94
virus perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.63   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.63   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (412)

Explore Interacting Targets

1 – 10 of 412

• See Interactions on String-DB

ZC3HAV1

Tbio

Novelty:  0.01357759

p_int:  0.963292725

p_ni:  0.036707273

p_wrong:  2e-9

Score:  0.245

Data Source:  BioPlex,STRINGDB

NAP1L1

Tbio

Novelty:  0.03895314

p_int:  0.956729582

p_ni:  0.043270418

Score:  0.339

Data Source:  BioPlex,STRINGDB

MAGEB10

Tdark

Novelty:  2.96156972

p_int:  0.906391634

p_ni:  0.093608366

Data Source:  BioPlex

SART3

Tbio

Novelty:  0.02353492

p_int:  0.90315376

p_ni:  0.09684624

Data Source:  BioPlex

DGCR8

Tbio

Novelty:  0.00271221

p_int:  0.900797868

p_ni:  0.099202132

Data Source:  BioPlex

RRS1

Tbio

Novelty:  0.01643671

p_int:  0.802959409

p_ni:  0.197040591

Score:  0.51

Data Source:  BioPlex,STRINGDB

MECP2

Tchem

Family:  TF

Novelty:  0.00051767

p_int:  0.775991738

p_ni:  0.224008262

Data Source:  BioPlex

ZNF71

Tbio

Family:  TF

Novelty:  0.24703192

p_int:  0.775991738

p_ni:  0.224008262

Data Source:  BioPlex

ZNF2

Tbio

Family:  TF

Novelty:  0.01062543

p_int:  0.766270976

p_ni:  0.233729024

Score:  0.201

Data Source:  BioPlex,STRINGDB

RPL32

Tbio

Novelty:  0.00279161

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (34)

Reactome (32)

KEGG (1)

WikiPathways (1)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (2)

Components (3)

Processes (5)

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1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	12	8	18	5	99.6
apolipoprotein A 1 measurement	EFO_0004614	2	5	6		98.9
total cholesterol measurement	EFO_0004574	6	5	11		98.5
BMI-adjusted hip circumference	EFO_0008039	2	8	11		92.8
body height	EFO_0004339	1	1	1		76.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	18	5	99.6
apolipoprotein A 1 measurement	EFO_0004614	6		98.9
total cholesterol measurement	EFO_0004574	11		98.5
BMI-adjusted hip circumference	EFO_0008039	11		92.8
body height	EFO_0004339	1		76.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Reference proteome
Ribonucleoprotein
Ribosomal protein

GWAS Trait Find Similar Targets

No Header	No Header
anthropometric measurement
apolipoprotein A 1 measurement
appendicular lean mass
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
C-reactive protein measurement
esterified cholesterol measurement
grip strength measurement
high density lipoprotein cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	ribosomal protein L17	MGI:2448270	319195
Rat	ribosomal protein L17	RGD:1303019	291434
Cow	ribosomal protein L17		514046
Xenopus	ribosomal protein L17	XB-GENE-5859417	448653
Zebrafish	ribosomal protein L17	ZDB-GENE-030131-8585	336641

Species	Name	OMA	EggNOG	Inparanoid
Mouse	ribosomal protein L17
Rat	ribosomal protein L17
Cow	ribosomal protein L17
Xenopus	ribosomal protein L17
Zebrafish	ribosomal protein L17

Publication Statistics

PubMed Score 34.63

PubMed score by year

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PubTator Score 41.24

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (1)

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PMID	Year	Title