Tbio NELFE Negative elongation factor E

Protein Summary

Description

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P18615
• A2BE08
• B4DUN1
• B4DYX9
• Q5JP74
• Q5JP75
• Q96F56
• Q9NPK2
• NELF-E

Gene Name

• NELFE

Ensembl ID

• ENST00000375425
• ENSP00000364574
• ENSG00000204356
• ENST00000375429
• ENSP00000364578
• ENST00000383174
• ENSP00000372660
• ENSG00000206268
• ENST00000383343
• ENSP00000372834
• ENSG00000206357
• ENST00000429857
• ENSP00000403623
• ENSG00000231044
• ENST00000444811
• ENSP00000388400
• ENST00000448628
• ENSP00000394879
• ENSG00000229363
• ENST00000457397
• ENSP00000393005
• ENSG00000233801

Symbol

• RD
• RDBP
• RD
• RDP
• RDBP
• D6S45
• NELF-E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
phenotype	0.79
interacting protein	0.76
biological process	0.75
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.77   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.77   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0