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Tbio
NELFE
Negative elongation factor E

Protein Summary
Description
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). Th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375425
  • ENSP00000364574
  • ENSG00000204356
  • ENST00000375429
  • ENSP00000364578
  • ENST00000383174
  • ENSP00000372660
  • ENSG00000206268
  • ENST00000383343
  • ENSP00000372834
  • ENSG00000206357
  • ENST00000429857
  • ENSP00000403623
  • ENSG00000231044
  • ENST00000444811
  • ENSP00000388400
  • ENST00000448628
  • ENSP00000394879
  • ENSG00000229363
  • ENST00000457397
  • ENSP00000393005
  • ENSG00000233801

Symbol
  • RD
  • RDBP
  • RD
  • RDP
  • RDBP
  • D6S45
  • NELF-E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
phenotype
0.79
interacting protein
0.76
biological process
0.75
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.51   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.51   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (114)
1 – 10 of 114
NELFA
Tbio
Novelty: 0.14037249
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NELFCD
Tbio
Novelty: 0.0012081
p_int: 0.999999989
p_ni: 9e-9
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NELFB
Tbio
Novelty: 0.07360458
p_int: 0.999999983
p_ni: 1e-8
p_wrong: 7e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
IGHMBP2
Tbio
Novelty: 0.01301411
p_int: 0.999986156
p_ni: 0.000002681
p_wrong: 0.000011164
Score: 0.681
Data Source: BioPlex,STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00199177
p_int: 0.998892117
p_ni: 0.00110788
p_wrong: 4e-9
Score: 0.691
Data Source: BioPlex,STRINGDB
CYP2J2
Tchem
Novelty: 0.00634057
p_int: 0.997102325
p_ni: 0.00289629
p_wrong: 0.000001385
Data Source: BioPlex
DIS3
Tbio
Family: Enzyme
Novelty: 0.01227304
p_int: 0.873941401
p_ni: 0.126058599
Score: 0.211
Data Source: BioPlex,STRINGDB
NCBP1
Tbio
Novelty: 0.00408393
Score: 0.999
Data Source: Reactome,STRINGDB
SUPT4H1
Tbio
Novelty: 0.01941463
Score: 0.991
Data Source: Reactome,STRINGDB
SUPT5H
Tbio
Novelty: 0.01008831
Score: 0.986
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  28.51

PubMed score by year
PubTator Score  46.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer