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Tbio
NELFE
Negative elongation factor E

Protein Summary
Description
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). Th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375425
  • ENSP00000364574
  • ENSG00000204356
  • ENST00000375429
  • ENSP00000364578
  • ENST00000383174
  • ENSP00000372660
  • ENSG00000206268
  • ENST00000383343
  • ENSP00000372834
  • ENSG00000206357
  • ENST00000429857
  • ENSP00000403623
  • ENSG00000231044
  • ENST00000444811
  • ENSP00000388400
  • ENST00000448628
  • ENSP00000394879
  • ENSG00000229363
  • ENST00000457397
  • ENSP00000393005
  • ENSG00000233801

Symbol
  • RD
  • RDBP
  • RD
  • RDP
  • RDBP
  • D6S45
  • NELF-E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
phenotype
0.79
interacting protein
0.76
biological process
0.75
tissue sample
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.56   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.56   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (76)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
9
0
1.9
99.3
6
6
0
2.3
99.2
3
5
0
1.8
98.7
BMI-adjusted waist-hip ratio
5
21
26
98
atrophic macular degeneration
2
3
0
1.8
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
99.3
0
2.3
99.2
0
1.8
98.7
BMI-adjusted waist-hip ratio
26
98
atrophic macular degeneration
0
1.8
97.4
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102744
27632
Rat
RGD:1303325
294258
Cow
negative elongation factor complex member E
VGNC:32002
540158
Zebrafish
ZDB-GENE-040718-69
436648
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
negative elongation factor complex member E
Zebrafish
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18615-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (114)
1 – 10 of 114
NELFA
Tbio
Novelty:  0.09727823
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NELFCD
Tbio
Novelty:  0.00094754
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NELFB
Tbio
Novelty:  0.05821821
p_int:  0.999999983
p_ni:  1e-8
p_wrong:  7e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
p_int:  0.999986156
p_ni:  0.000002681
p_wrong:  0.000011164
Score:  0.681
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.998892117
p_ni:  0.00110788
p_wrong:  4e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.997102325
p_ni:  0.00289629
p_wrong:  0.000001385
Data Source:  BioPlex
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
p_int:  0.873941401
p_ni:  0.126058599
Score:  0.211
Data Source:  BioPlex,STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.999
Data Source:  Reactome,STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.991
Data Source:  Reactome,STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.986
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  48.56

PubMed score by year
PubTator Score  46.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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