You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PDE6G
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Protein Classes
Protein Summary
Description
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331056
  • ENSP00000328412
  • ENSG00000185527
  • ENST00000571004
  • ENSP00000461464
  • ENST00000571224
  • ENSP00000458167

Symbol
  • PDEG
  • PDEG
  • RP57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
biological process
0.71
cell line
0.61
tissue sample
0.61
cellular component
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dipyridamole
Rendered image for dipyridamole
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.1
96.9
Myopia
3
3
0
1.2
86.3
refractive error measurement
2
3
2
5.9
84.6
ganglion cell inner plexiform layer thickness measurement
1
1
1
79.5
mathematical ability
4
2
4
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
96.9
Myopia
0
1.2
86.3
refractive error measurement
2
5.9
84.6
ganglion cell inner plexiform layer thickness measurement
1
79.5
mathematical ability
4
77.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97526
18588
Rat
RGD:1591130
688297
Dog
phosphodiesterase 6G
VGNC:44361
403911
Horse
phosphodiesterase 6G
VGNC:21252
100055790
Cow
phosphodiesterase 6G
VGNC:32683
281977
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphodiesterase 6G
Horse
phosphodiesterase 6G
Cow
phosphodiesterase 6G
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18545-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Beta-catenin independent WNT signaling
Ca2+ pathway
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (160)
1 – 10 of 160
PDE6A
Tclin
Family:  Enzyme
Novelty:  0.02680494
Score:  0.996
Data Source:  Reactome,STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.995
Data Source:  Reactome,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.993
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.988
Data Source:  Reactome,STRINGDB
GNG11
Tbio
Novelty:  0.10721743
Score:  0.985
Data Source:  STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.982
Data Source:  Reactome,STRINGDB
RGS9
Tbio
Novelty:  0.06662559
Score:  0.974
Data Source:  STRINGDB
PDE2A
Tclin
Family:  Enzyme
Novelty:  0.00862513
Score:  0.973
Data Source:  STRINGDB
CNGA1
Tchem
Family:  IC
Novelty:  0.00848214
Score:  0.969
Data Source:  STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.963
Data Source:  STRINGDB
Publication Statistics
PubMed Score  34.85

PubMed score by year
PubTator Score  6.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: