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Tchem
IL1RN
Interleukin-1 receptor antagonist protein

Protein Summary
Description
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259206
  • ENSP00000259206
  • ENSG00000136689
  • ENST00000354115
  • ENSP00000329072
  • ENST00000361779
  • ENSP00000354816
  • ENST00000409052
  • ENSP00000387210
  • ENST00000409930
  • ENSP00000387173

Symbol
  • IL1F3
  • IL1RA
  • DIRA
  • IRAP
  • IL1F3
  • IL1RA
  • MVCD4
  • IL-1RN
  • IL-1ra
  • IL-1ra3
  • ICIL-1RA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
disease
0.93
gene perturbation
0.8
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1514.97   (req: < 5)
Gene RIFs: 492   (req: <= 3)
Antibodies: 806   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1514.97   (req: >= 5)
Gene RIFs: 492   (req: > 3)
Antibodies: 806   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
rilonacept
no chemical structure image available
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
97.1
red blood cell distribution width
2
1
2
70.1
neutrophil percentage of leukocytes
2
2
2
68.4
neutrophil count
1
1
1
50
lymphocyte percentage of leukocytes
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
97.1
red blood cell distribution width
2
70.1
neutrophil percentage of leukocytes
2
68.4
neutrophil count
1
50
lymphocyte percentage of leukocytes
1
48.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor antagonist
VGNC:10686
459501
Macaque
interleukin 1 receptor antagonist
701658
Mouse
MGI:96547
16181
Rat
RGD:621159
60582
Dog
interleukin 1 receptor antagonist
VGNC:41962
403660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor antagonist
Macaque
interleukin 1 receptor antagonist
Mouse
Rat
Dog
interleukin 1 receptor antagonist
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18510-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (124)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Interleukin-10 signaling
Gene Ontology Terms (27)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (157)
1 – 10 of 157
FTH1
Tbio
Novelty: 0.000863
p_int: 0.999166597
p_ni: 0.000698914
p_wrong: 0.000134489
Score: 0.206
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.998832302
p_ni: 0.000959899
p_wrong: 0.000207798
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.998644731
p_ni: 0.001355267
p_wrong: 2e-9
Data Source: BioPlex
SEC22C
Tdark
Novelty: 0.53697928
p_int: 0.995880121
p_ni: 0.004119868
p_wrong: 1.1e-8
Score: 0.455
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.991958508
p_ni: 0.00804149
p_wrong: 2e-9
Data Source: BioPlex
GPIHBP1
Tbio
Novelty: 0.01241227
p_int: 0.776982318
p_ni: 0.004501448
p_wrong: 0.218516234
Data Source: BioPlex
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.764987968
p_ni: 0.121027905
p_wrong: 0.113984127
Score: 0.3
Data Source: BioPlex,STRINGDB
IL1R1
Tclin
Novelty: 0.0014281
Score: 0.998
Data Source: Reactome,STRINGDB
IL1A
Tchem
Novelty: 0.00019366
Score: 0.988
Data Source: STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1514.97

PubMed score by year
PubTator Score  2004.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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