Tbio ADCYAP1 Pituitary adenylate cyclase-activating polypeptide

Protein Summary

Description

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• P18509
• B2R7N4
• Q52LQ0
• PACAP

Gene Name

• ADCYAP1

Ensembl ID

• ENST00000450565
• ENSP00000411658
• ENSG00000141433
• ENST00000579794
• ENSP00000462647

Symbol

• PACAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
co-expressed gene	1
gene perturbation	0.9
biological term	0.76
microRNA	0.7

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Pituitary Adenylate Cyclase-activating Polypeptide

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Pituitary Adenylate Cyclase-activating Polypeptide

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1490.88   (req: < 5)

Gene RIFs: 106   (req: <= 3)

Antibodies: 252   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1490.88   (req: >= 5)

Gene RIFs: 106   (req: > 3)

Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0