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Tclin
GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2

Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414552
  • ENSP00000410732
  • ENSG00000113327
  • ENST00000639111
  • ENSP00000492125
  • ENST00000639213
  • ENSP00000491909

Symbol
  • CAE2
  • ECA2
  • GEFSP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.93
protein domain
0.92
chemical
0.91
gene perturbation
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.53   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.53   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 49
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (49)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
topiramate
Rendered image for topiramate
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (235)
GABRG1
Tclin
Family:  IC
Novelty:  0.04214561
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.998477408
p_ni:  0.001522592
Data Source:  BioPlex
P10314
Tbio
Novelty:  0.00270731
p_int:  0.99542299
p_ni:  0.00457701
Data Source:  BioPlex
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.981796317
p_ni:  0.018203683
Score:  0.209
Data Source:  BioPlex,STRINGDB
BSCL2
Tbio
Novelty:  0.00483959
p_int:  0.960329754
p_ni:  0.039670246
Score:  0.192
Data Source:  BioPlex,STRINGDB
B4GALT5
Tbio
Family:  Enzyme
Novelty:  0.04538678
p_int:  0.942194177
p_ni:  0.055648656
p_wrong:  0.002157167
Score:  0.179
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.940658917
p_ni:  0.059341083
Data Source:  BioPlex
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.878915522
p_ni:  0.121084477
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
LCLAT1
Tbio
Family:  Enzyme
Novelty:  0.03234576
p_int:  0.850142559
p_ni:  0.149841162
p_wrong:  0.000016279
Score:  0.183
Data Source:  BioPlex,STRINGDB
ABHD14A
Tdark
Family:  Enzyme
Novelty:  0.77988335
p_int:  0.818280218
p_ni:  0.181700267
p_wrong:  0.000019516
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
1
1
0
3.2
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
0
3.2
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor gamma2 subunit
697248
Mouse
MGI:95623
14406
Rat
RGD:61966
29709
Dog
gamma-aminobutyric acid type A receptor gamma2 subunit
VGNC:41064
489141
Horse
gamma-aminobutyric acid type A receptor gamma2 subunit
VGNC:18202
100059571
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor gamma2 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor gamma2 subunit
Horse
gamma-aminobutyric acid type A receptor gamma2 subunit
Publication Statistics
PubMed Score 126.53
PubMed score by year
PubTator Score 114.83
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title