GABRB1
Gamma-aminobutyric acid receptor subunit beta-1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug | 1 | ||
gene perturbation | 0.96 | ||
molecular function | 0.86 | ||
trait | 0.86 | ||
protein domain | 0.85 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | GABA receptor activation | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by ERBB4 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
GABA receptor activation | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Signal Transduction | ||||
Signaling by ERBB4 | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
risk-taking behaviour | 3 | 2 | 3 | 72.1 | |||||
mathematical ability | 4 | 3 | 4 | 64.9 | |||||
self reported educational attainment | 1 | 1 | 1 | 31.4 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 24.5 | |||||
alcohol use disorder measurement | 1 | 1 | 1 | 24.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
risk-taking behaviour | 3 | 72.1 | |||||
mathematical ability | 4 | 64.9 | |||||
self reported educational attainment | 1 | 31.4 | |||||
alcohol consumption measurement | 1 | 24.5 | |||||
alcohol use disorder measurement | 1 | 24.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | gamma-aminobutyric acid type A receptor beta1 subunit | VGNC:10880 | 461352 | |||||
Mouse | MGI:95619 | 14400 | ||||||
Rat | RGD:2649 | 25450 | ||||||
Cow | gamma-aminobutyric acid type A receptor beta1 subunit | VGNC:29196 | 282239 | |||||
Opossum | gamma-aminobutyric acid type A receptor beta1 subunit | 100014538 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Mouse | ||||||
Rat | ||||||
Cow | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Opossum | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
PMID | Year | Title |
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