GABRB1
Gamma-aminobutyric acid receptor subunit beta-1
Protein Classes
Protein Summary
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]
- ENST00000295454
- ENSP00000295454
- ENSG00000163288
- ENST00000510909
- ENSP00000426766
- EIEE45
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
gene perturbation | 0.96 | ||
molecular function | 0.86 | ||
trait | 0.86 | ||
protein domain | 0.85 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.21 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 417 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.21 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 417 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 14
Approved Drugs (14)
1 – 10 of 14
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
risk-taking behaviour | 3 | 2 | 3 | 72.1 | |||||
mathematical ability | 4 | 3 | 4 | 64.9 | |||||
self reported educational attainment | 1 | 1 | 1 | 31.4 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 24.5 | |||||
alcohol use disorder measurement | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
risk-taking behaviour | 3 | 72.1 | |||||
mathematical ability | 4 | 64.9 | |||||
self reported educational attainment | 1 | 31.4 | |||||
alcohol consumption measurement | 1 | 24.5 | |||||
alcohol use disorder measurement | 1 | 24.5 | |||||
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gamma-aminobutyric acid type A receptor beta1 subunit | VGNC:10880 | 461352 | |||||
Mouse | MGI:95619 | 14400 | ||||||
Rat | RGD:2649 | 25450 | ||||||
Cow | gamma-aminobutyric acid type A receptor beta1 subunit | VGNC:29196 | 282239 | |||||
Opossum | gamma-aminobutyric acid type A receptor beta1 subunit | 100014538 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Mouse | ||||||
Rat | ||||||
Cow | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Opossum | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (20)
Reactome (7)
KEGG (6)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | GABA receptor activation | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by ERBB4 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GABA receptor activation | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Signal Transduction | ||||
Signaling by ERBB4 | ||||
Gene Ontology Terms (30)
Functions (5)
Components (12)
Processes (13)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (146)
1 – 10 of 146
GABRG2
Family: IC
Novelty: 0.00819163
Score: 0.98
Data Source: Reactome,STRINGDB
GABRA1
Family: IC
Novelty: 0.0094079
Score: 0.978
Data Source: Reactome,STRINGDB
GABRA5
Family: IC
Novelty: 0.01499706
Score: 0.978
Data Source: STRINGDB
GABRA4
Family: IC
Novelty: 0.03089903
Score: 0.966
Data Source: STRINGDB
GABRA2
Family: IC
Novelty: 0.00663529
Score: 0.963
Data Source: STRINGDB
GABRA6
Family: IC
Novelty: 0.02894664
Score: 0.962
Data Source: STRINGDB
GABRA3
Family: IC
Novelty: 0.02180091
Score: 0.959
Data Source: STRINGDB
GABRG3
Family: IC
Novelty: 0.0420649
Score: 0.94
Data Source: Reactome,STRINGDB
ARHGEF9
Novelty: 0.01577146
Score: 0.917
Data Source: STRINGDB
NPTN
Novelty: 0.00405661
Score: 0.909
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 33.21
PubMed score by year
PubTator Score 19.59
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
GWAS Trait
No Header | No Header | ||
|---|---|---|---|