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Tclin
GABRB1
Gamma-aminobutyric acid receptor subunit beta-1

Protein Classes
Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295454
  • ENSP00000295454
  • ENSG00000163288
  • ENST00000510909
  • ENSP00000426766

Symbol
  • EIEE45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.96
molecular function
0.86
trait
0.86
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.21   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.21   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Approved Drugs (14)
1 – 10 of 14
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
3
2
3
72.1
mathematical ability
4
3
4
64.9
self reported educational attainment
1
1
1
31.4
alcohol consumption measurement
1
1
1
24.5
alcohol use disorder measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
3
72.1
mathematical ability
4
64.9
self reported educational attainment
1
31.4
alcohol consumption measurement
1
24.5
alcohol use disorder measurement
1
24.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor beta1 subunit
VGNC:10880
461352
Mouse
MGI:95619
14400
Rat
RGD:2649
25450
Cow
gamma-aminobutyric acid type A receptor beta1 subunit
VGNC:29196
282239
Opossum
gamma-aminobutyric acid type A receptor beta1 subunit
100014538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor beta1 subunit
Mouse
Rat
Cow
gamma-aminobutyric acid type A receptor beta1 subunit
Opossum
gamma-aminobutyric acid type A receptor beta1 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P18505-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (146)
1 – 10 of 146
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.98
Data Source:  Reactome,STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.978
Data Source:  Reactome,STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.978
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.966
Data Source:  STRINGDB
GABRA2
Tclin
Family:  IC
Novelty:  0.00663529
Score:  0.963
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.962
Data Source:  STRINGDB
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
Score:  0.959
Data Source:  STRINGDB
GABRG3
Tclin
Family:  IC
Novelty:  0.0420649
Score:  0.94
Data Source:  Reactome,STRINGDB
ARHGEF9
Tbio
Novelty:  0.01577146
Score:  0.917
Data Source:  STRINGDB
NPTN
Tbio
Novelty:  0.00405661
Score:  0.909
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  33.21

PubMed score by year
PubTator Score  19.59

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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