GABRB1
Gamma-aminobutyric acid receptor subunit beta-1
Protein Summary
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]
- ENST00000295454
- ENSP00000295454
- ENSG00000163288
- ENST00000510909
- ENSP00000426766
- EIEE45
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
gene perturbation | 0.96 | ||
molecular function | 0.86 | ||
trait | 0.86 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.21 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 417 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.21 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 417 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 14
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (14)
Active Ligands (0)
Protein-Protein Interactions (146)
Nearest Tclin Targets
Pathways (20)
Reactome (7)
KEGG (6)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | GABA receptor activation | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by ERBB4 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GABA receptor activation | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Signal Transduction | ||||
Signaling by ERBB4 | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (5)
Components (12)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
risk-taking behaviour | 3 | 2 | 3 | 72.1 | |||||
mathematical ability | 4 | 3 | 4 | 64.9 | |||||
self reported educational attainment | 1 | 1 | 1 | 31.4 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 24.5 | |||||
alcohol use disorder measurement | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
risk-taking behaviour | 3 | 72.1 | |||||
mathematical ability | 4 | 64.9 | |||||
self reported educational attainment | 1 | 31.4 | |||||
alcohol consumption measurement | 1 | 24.5 | |||||
alcohol use disorder measurement | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gamma-aminobutyric acid type A receptor beta1 subunit | VGNC:10880 | 461352 | |||||
Mouse | MGI:95619 | 14400 | ||||||
Rat | RGD:2649 | 25450 | ||||||
Cow | gamma-aminobutyric acid type A receptor beta1 subunit | VGNC:29196 | 282239 | |||||
Opossum | gamma-aminobutyric acid type A receptor beta1 subunit | 100014538 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Mouse | ||||||
Rat | ||||||
Cow | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Opossum | gamma-aminobutyric acid type A receptor beta1 subunit | |||||
Publication Statistics
PubMed Score 33.21
PubMed score by year
PubTator Score 19.59
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (52)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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