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Tchem
NAT1
Arylamine N-acetyltransferase 1

Protein Summary
Description
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307719
  • ENSP00000307218
  • ENSG00000171428
  • ENST00000517492
  • ENSP00000429407
  • ENST00000518029
  • ENSP00000428270
  • ENST00000520546
  • ENSP00000429341
  • ENST00000541942
  • ENSP00000440900

Symbol
  • AAC1
  • AAC1
  • MNAT
  • NATI
  • NAT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.85
virus perturbation
0.85
cell type or tissue
0.84
biological term
0.83
disease
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.91   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.91   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Acetylation (R-HSA-156582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylation
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Acetylation
Biological oxidations
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (43)
1 – 10 of 43
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.999609318
p_ni: 0.000390678
p_wrong: 4e-9
Score: 0.537
Data Source: BioPlex,STRINGDB
CYP2E1
Tchem
Novelty: 0.00030504
Score: 0.951
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.947
Data Source: STRINGDB
CYP2A6
Tchem
Novelty: 0.00105285
Score: 0.923
Data Source: STRINGDB
MPO
Tchem
Family: Enzyme
Novelty: 0.00020698
Score: 0.922
Data Source: STRINGDB
CES1
Tchem
Family: Enzyme
Novelty: 0.00092608
Score: 0.914
Data Source: STRINGDB
XDH
Tclin
Family: Enzyme
Novelty: 0.00054185
Score: 0.903
Data Source: STRINGDB
NAT2
Tbio
Family: Enzyme
Novelty: 0.00150849
Score: 0.85
Data Source: STRINGDB
GATD3B
Tdark
Novelty: 0.00433938
Score: 0.792
Data Source: STRINGDB
GATD3A
Tdark
Novelty: 0.00423462
Score: 0.792
Data Source: STRINGDB
Publication Statistics
PubMed Score  250.91

PubMed score by year
PubTator Score  382.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer