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Tchem
PTPRA
Receptor-type tyrosine-protein phosphatase alpha

Protein Summary
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216877
  • ENSP00000216877
  • ENSG00000132670
  • ENST00000318266
  • ENSP00000314568
  • ENST00000356147
  • ENSP00000348468
  • ENST00000380393
  • ENSP00000369756
  • ENST00000399903
  • ENSP00000382787

Symbol
  • PTPA
  • PTPRL2
  • LRP
  • HLPR
  • PTPA
  • HEPTP
  • HPTPA
  • RPTPA
  • PTPRL2
  • HPTPalpha
  • R-PTP-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
protein domain
0.85
virus perturbation
0.76
transcription factor
0.74
tissue sample
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.19   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.19   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
61.2
myeloid white cell count
1
1
1
55.7
body mass index
1
1
1
53.2
reticulocyte measurement
2
1
2
35
reticulocyte count
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
61.2
myeloid white cell count
1
55.7
body mass index
1
53.2
reticulocyte measurement
2
35
reticulocyte count
1
23
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type A
VGNC:9944
746684
Macaque
protein tyrosine phosphatase, receptor type A
574364
Mouse
MGI:97808
19262
Rat
RGD:3450
25167
Dog
protein tyrosine phosphatase, receptor type A
VGNC:45182
477176
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type A
Macaque
protein tyrosine phosphatase, receptor type A
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P18433-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
Protein-Protein Interactions (103)
1 – 10 of 103
PTPRE
Tbio
Family: Enzyme
Novelty: 0.04184946
p_int: 1
Score: 0.529
Data Source: BioPlex,STRINGDB
ASNSD1
Tdark
Family: Enzyme
Novelty: 0.54006324
p_int: 0.999999969
p_ni: 1.2e-8
p_wrong: 1.9e-8
Score: 0.21
Data Source: BioPlex,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.999999943
p_ni: 5.7e-8
Score: 0.846
Data Source: BioPlex,Reactome,STRINGDB
DENND4A
Tbio
Novelty: 0.22983311
p_int: 0.999927511
p_ni: 0.000072473
p_wrong: 1.5e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.998536699
p_ni: 0.000027812
p_wrong: 0.001435488
Score: 0.158
Data Source: BioPlex,STRINGDB
SP4
Tbio
Family: TF
Novelty: 0.02444442
p_int: 0.995154081
p_ni: 0.004845919
Score: 0.2
Data Source: BioPlex,STRINGDB
FCN1
Tbio
Novelty: 0.01037775
p_int: 0.992913137
p_ni: 0.00708686
p_wrong: 3e-9
Score: 0.224
Data Source: BioPlex,STRINGDB
CYB561
Tbio
Novelty: 0.15317924
p_int: 0.977881364
p_wrong: 0.022118636
Score: 0.369
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.975610418
p_ni: 0.024389575
p_wrong: 7e-9
Data Source: BioPlex
GALNT12
Tbio
Family: Enzyme
Novelty: 0.085131
p_int: 0.963251039
p_ni: 0.036748951
p_wrong: 1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  77.19

PubMed score by year
PubTator Score  87.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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