PTPRA
Receptor-type tyrosine-protein phosphatase alpha
Protein Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
- ENST00000216877
- ENSP00000216877
- ENSG00000132670
- ENST00000318266
- ENSP00000314568
- ENST00000356147
- ENSP00000348468
- ENST00000380393
- ENSP00000369756
- ENST00000399903
- ENSP00000382787
- PTPA
- PTPRL2
- LRP
- HLPR
- PTPA
- HEPTP
- HPTPA
- RPTPA
- PTPRL2
- HPTPalpha
- R-PTP-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
protein domain | 0.85 | ||
virus perturbation | 0.76 | ||
transcription factor | 0.74 | ||
tissue sample | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.14 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 470 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.14 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 470 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0