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Tbio
LBP
Lipopolysaccharide-binding protein

Protein Summary
Description
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217407
  • ENSP00000217407
  • ENSG00000129988

Symbol
  • BPIFD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
disease perturbation
0.93
gene perturbation
0.84
disease
0.77
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.82   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 375   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.82   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
CD14
Tbio
Novelty:  0.00872424
Score:  0.98
Data Source:  Reactome,STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.966
Data Source:  STRINGDB
LY96
Tchem
Novelty:  0.00123253
Score:  0.966
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.919
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.917
Data Source:  STRINGDB
BPI
Tbio
Novelty:  0.00229665
Score:  0.906
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.906
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.902
Data Source:  STRINGDB
BPIFA1
Tbio
Novelty:  0.00586117
Score:  0.719
Data Source:  STRINGDB
HP
Tbio
Novelty:  0.00016649
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Regulation of TLR by endogenous ligand
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-4 and Interleukin-13 signaling
Regulation of TLR by endogenous ligand
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
2
2
66.6
myeloid white cell count
1
1
1
11.3
basophil count
1
1
1
10.3
basophil percentage of leukocytes
1
1
1
8.2
leukocyte count
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
66.6
myeloid white cell count
1
11.3
basophil count
1
10.3
basophil percentage of leukocytes
1
8.2
leukocyte count
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipopolysaccharide binding protein
VGNC:14254
458239
Macaque
lipopolysaccharide binding protein
706109
Mouse
MGI:1098776
16803
Rat
RGD:61865
29469
Horse
lipopolysaccharide binding protein
VGNC:19600
100070103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipopolysaccharide binding protein
Macaque
lipopolysaccharide binding protein
Mouse
Rat
Horse
lipopolysaccharide binding protein
Publication Statistics
PubMed Score 458.82
PubMed score by year
PubTator Score 926.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title