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Tbio
VCL
Vinculin

Protein Summary
Description
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211998
  • ENSP00000211998
  • ENSG00000035403
  • ENST00000372755
  • ENSP00000361841

Symbol
  • MV
  • MVCL
  • CMD1W
  • CMH15
  • HEL114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.97
virus perturbation
0.96
transcription factor binding site profile
0.92
hub protein
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2180.22   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2180.22   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular diastolic function measurement
1
1
1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular diastolic function measurement
1
22.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vinculin
VGNC:5875
450531
Mouse
MGI:98927
22330
Rat
RGD:1311217
305679
Dog
vinculin
VGNC:48242
479252
Horse
vinculin
VGNC:24892
100064165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vinculin
Mouse
Rat
Dog
vinculin
Horse
vinculin
Protein Structure (31 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18206-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Hemostasis
Gene Ontology Terms (47)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (448)
1 – 10 of 448
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.999
Data Source: STRINGDB
TLN1
Tbio
Novelty: 0.00803981
Score: 0.999
Data Source: Reactome,STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.999
Data Source: STRINGDB
ACTN4
Tbio
Novelty: 0.0040236
Score: 0.998
Data Source: STRINGDB
CTNNA1
Tbio
Novelty: 0.00925774
Score: 0.998
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.992
Data Source: STRINGDB
TLN2
Tbio
Novelty: 0.0284423
Score: 0.991
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.991
Data Source: Reactome,STRINGDB
ACTN3
Tbio
Novelty: 0.00375035
Score: 0.99
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  2180.22

PubMed score by year
PubTator Score  1276.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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