Tbio EGR1 Early growth response protein 1

Protein Summary

Description

Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• P18146
• EGR-1

Gene Name

• EGR1

Ensembl ID

• ENST00000239938
• ENSP00000239938
• ENSG00000120738

Symbol

• KROX24
• ZNF225
• TIS8
• AT225
• G0S30
• NGFI-A
• ZNF225
• KROX-24
• ZIF-268

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
gene perturbation	1
PubMedID	1
small molecule perturbation	1
virus perturbation	1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Early Growth Response Protein 1

Protein / Transcription Factor / Transcription Cofactor / Early Growth Response Protein 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Early Growth Response Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Early Growth Response Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2831.47   (req: < 5)

Gene RIFs: 465   (req: <= 3)

Antibodies: 504   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2831.47   (req: >= 5)

Gene RIFs: 465   (req: > 3)

Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0