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Tbio
RPL7
60S ribosomal protein L7

Protein Summary
Description
Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352983
  • ENSP00000339795
  • ENSG00000147604

Symbol
  • L7
  • humL7-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
virus perturbation
0.96
small molecule perturbation
0.91


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.35   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.35   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L7
698049
Mouse
MGI:98073
19989
Rat
RGD:735169
297755
Dog
ribosomal protein L7
477912
Horse
ribosomal protein L7
100034008
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein L7
Mouse
Rat
Dog
ribosomal protein L7
Horse
ribosomal protein L7
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18124-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (507)
1 – 10 of 507
CBX2
Tchem
Family:  Epigenetic
Novelty:  0.01952928
p_int:  0.999985243
p_ni:  0.000014757
Score:  0.21
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.989435396
p_ni:  0.010564602
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
BMI1
Tbio
Novelty:  0.00158043
p_int:  0.987665534
p_ni:  0.012334466
Score:  0.159
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.986200695
p_ni:  0.013799305
Score:  0.997
Data Source:  BioPlex,STRINGDB
PHC2
Tbio
Novelty:  0.01943349
p_int:  0.980739865
p_ni:  0.019260134
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZNF689
Tdark
Family:  TF
Novelty:  1.03726427
p_int:  0.973563319
p_ni:  0.02181277
p_wrong:  0.004623912
Data Source:  BioPlex
TSPYL2
Tbio
Novelty:  0.03720016
p_int:  0.956403791
p_ni:  0.043559225
p_wrong:  0.000036984
Score:  0.198
Data Source:  BioPlex,STRINGDB
ZNF22
Tbio
Family:  TF
Novelty:  0.12323788
p_int:  0.950585183
p_ni:  0.049414817
Score:  0.157
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.9449587
p_ni:  0.055041299
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
NOC4L
Tdark
Novelty:  0.39929311
p_int:  0.935433347
p_ni:  0.064566653
Score:  0.404
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  174.35

PubMed score by year
PubTator Score  40.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer