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Tclin
ADRA2B
Alpha-2B adrenergic receptor

Protein Summary
Description
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620793
  • ENSP00000480573
  • ENSG00000274286

Symbol
  • ADRA2L1
  • ADRA2RL1
  • FAME2
  • ADRA2L1
  • ADRARL1
  • ADRA2RL1
  • ALPHA2BAR
  • alpha-2BAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological process
0.95
ligand (chemical)
0.94
cell type or tissue
0.76
biological term
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.46   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.46   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 54
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (317)
1 – 10 of 317
NPY
Tbio
Novelty:  0.00012637
Score:  0.965
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.956
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.955
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.947
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.943
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.943
Data Source:  STRINGDB
AGTR2
Tchem
Family:  GPCR
Novelty:  0.00064774
Score:  0.941
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.937
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.936
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.935
Data Source:  STRINGDB
Pathways (19)
Adrenaline signalling through Alpha-2 adrenergic receptor (R-HSA-392023)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline signalling through Alpha-2 adrenergic receptor
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
62.8
monocyte percentage of leukocytes
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
62.8
monocyte percentage of leukocytes
1
13.6
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
adrenoceptor alpha 2B
694825
Mouse
MGI:87935
11552
Rat
RGD:2057
24174
Dog
adrenoceptor alpha 2B
VGNC:37675
100855976
Horse
adrenoceptor alpha 2B
VGNC:51273
100051684
Species
Name
OMA
EggNOG
Inparanoid
Macaque
adrenoceptor alpha 2B
Mouse
Rat
Dog
adrenoceptor alpha 2B
Horse
adrenoceptor alpha 2B
Publication Statistics
PubMed Score 158.46
PubMed score by year
PubTator Score 149.75
PubTator score by year
Patents
Patents by year