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Tbio
ITGB5
Integrin beta-5

Protein Summary
Description
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296181
  • ENSP00000296181
  • ENSG00000082781
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
protein domain
0.97
transcription factor perturbation
0.97
disease perturbation
0.96
protein complex
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.46   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.46   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
42
heel bone mineral density
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
42
heel bone mineral density
1
16.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 5
VGNC:6347
460646
Macaque
integrin subunit beta 5
715710
Mouse
MGI:96614
16419
Dog
integrin subunit beta 5
VGNC:42140
608977
Horse
integrin subunit beta 5
VGNC:19179
100070376
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 5
Macaque
integrin subunit beta 5
Mouse
Dog
integrin subunit beta 5
Horse
integrin subunit beta 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P18084-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (49)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of particulate exogenous antigens (phagosomes)
Reactome
ECM proteoglycans
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cross-presentation of particulate exogenous antigens (phagosomes)
ECM proteoglycans
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (184)
1 – 10 of 184
MFGE8
Tbio
Novelty: 0.00132919
p_int: 0.999904409
p_ni: 0.000095586
p_wrong: 5e-9
Score: 0.774
Data Source: BioPlex,STRINGDB
EDIL3
Tbio
Novelty: 0.00848858
p_int: 0.999620007
p_ni: 0.000361567
p_wrong: 0.000018426
Score: 0.918
Data Source: BioPlex,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.994651173
p_ni: 0.0032551
p_wrong: 0.002093727
Score: 0.965
Data Source: BioPlex,Reactome,STRINGDB
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.989424042
p_ni: 0.010575905
p_wrong: 5.3e-8
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.979007136
p_ni: 0.020009521
p_wrong: 0.000983343
Data Source: BioPlex
ADAM21
Tdark
Family: Enzyme
Novelty: 0.16068055
p_int: 0.968887914
p_ni: 0.030766429
p_wrong: 0.000345657
Data Source: BioPlex
ADAM33
Tchem
Family: Enzyme
Novelty: 0.00584097
p_int: 0.967241183
p_ni: 0.03172679
p_wrong: 0.001032027
Data Source: BioPlex
PRG3
Tbio
Novelty: 0.09431986
p_int: 0.962600933
p_ni: 0.03705744
p_wrong: 0.000341627
Data Source: BioPlex
ATP1B3
Tclin
Family: Transporter
Novelty: 0.06773518
p_int: 0.959226748
p_ni: 0.040355138
p_wrong: 0.000418115
Score: 0.164
Data Source: BioPlex,STRINGDB
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
p_int: 0.95662502
p_ni: 0.04275673
p_wrong: 0.00061825
Score: 0.152
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  61.46

PubMed score by year
PubTator Score  28.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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