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Tbio
RPL35A
60S ribosomal protein L35a

Protein Summary
Description
Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448864
  • ENSP00000393393
  • ENSG00000182899
  • ENST00000464167
  • ENSP00000419117
  • ENST00000647248
  • ENSP00000495672

Symbol
  • DBA5
  • L35A
  • eL33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
disease perturbation
0.96
kinase perturbation
0.96
biological process
0.75
small molecule perturbation
0.75


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.11   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.11   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L35a
VGNC:12178
744483
Mouse
MGI:1928894
57808
Dog
ribosomal protein L35a
VGNC:45719
478597
Horse
ribosomal protein L35a
VGNC:22529
100034007
Cow
ribosomal protein L35a
VGNC:53601
506768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L35a
Mouse
Dog
ribosomal protein L35a
Horse
ribosomal protein L35a
Cow
ribosomal protein L35a
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18077-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (452)
1 – 10 of 452
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.939641627
p_ni:  0.060358233
p_wrong:  1.4e-7
Score:  0.779
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.828380211
p_ni:  0.171619789
Score:  0.552
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.821127017
p_ni:  0.178872983
Score:  0.672
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.758467166
p_ni:  0.241532834
Score:  0.587
Data Source:  BioPlex,STRINGDB
RPS17
Tbio
Novelty:  0.00942675
Score:  0.999
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.999
Data Source:  STRINGDB
RPS9
Tbio
Novelty:  0.01329701
Score:  0.999
Data Source:  STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.11

PubMed score by year
PubTator Score  11.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer