You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BMP7
Bone morphogenetic protein 7

Protein Summary
Description
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395863
  • ENSP00000379204
  • ENSG00000101144

Symbol
  • OP1
  • OP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
biological term
0.97
kinase perturbation
0.91
gene perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2154   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 880   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2154   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 880   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 82
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
96.1
synophrys measurement
1
1
1
58.4
reticulocyte count
4
1
4
58
sex hormone-binding globulin measurement
1
1
1
50.4
metopic craniosynostosis
1
1
0
1.8
46.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
96.1
synophrys measurement
1
58.4
reticulocyte count
4
58
sex hormone-binding globulin measurement
1
50.4
metopic craniosynostosis
0
1.8
46.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 7
VGNC:6053
458357
Macaque
bone morphogenetic protein 7
696948
Mouse
MGI:103302
12162
Rat
RGD:620743
85272
Dog
bone morphogenetic protein 7
VGNC:38482
477270
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 7
Macaque
bone morphogenetic protein 7
Mouse
Rat
Dog
bone morphogenetic protein 7
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (86)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (231)
1 – 10 of 231
VWA8
Tdark
Novelty: 0.17546432
p_int: 0.999732646
p_ni: 0.000267354
Score: 0.518
Data Source: BioPlex,STRINGDB
PDCD10
Tbio
Novelty: 0.00683934
p_int: 0.999564843
p_ni: 0.000435157
Score: 0.189
Data Source: BioPlex,STRINGDB
STK26
Tchem
Family: Kinase
Novelty: 0.03633178
p_int: 0.996874958
p_ni: 0.003125042
Score: 0.523
Data Source: BioPlex,STRINGDB
GDF11
Tclin
Novelty: 0.00585981
p_int: 0.995384026
p_ni: 0.003406765
p_wrong: 0.001209209
Score: 0.334
Data Source: BioPlex,STRINGDB
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.977038938
p_ni: 0.022961062
Data Source: BioPlex
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.955525647
p_ni: 0.044474353
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.953698322
p_ni: 0.046300738
p_wrong: 9.4e-7
Data Source: BioPlex
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.93479378
p_ni: 0.065206187
p_wrong: 3.3e-8
Score: 0.201
Data Source: BioPlex,STRINGDB
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.924382456
p_ni: 0.075617243
p_wrong: 3.01e-7
Data Source: BioPlex
OLFM2
Tbio
Novelty: 0.06929963
p_int: 0.921031678
p_ni: 0.078968306
p_wrong: 1.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  2154.00

PubMed score by year
PubTator Score  879.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: