Tchem IGFBP2 Insulin-like growth factor-binding protein 2

Protein Summary

Description

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P18065
• Q14619
• Q9UCL3
• IBP-2

Gene Name

• IGFBP2

Ensembl ID

• ENST00000233809
• ENSP00000233809
• ENSG00000115457

Symbol

• BP2
• IBP2
• IBP2
• IGF-BP53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
PubMedID	1
protein domain	0.92
transcription factor perturbation	0.88
disease	0.86

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 2

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1405.08   (req: < 5)

Gene RIFs: 231   (req: <= 3)

Antibodies: 413   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1405.08   (req: >= 5)

Gene RIFs: 231   (req: > 3)

Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0